Nicotine and cotinine modulate eicosanoid production in human leukocytes and platelet rich plasma

Virpi Saareks, Asko Riutta, István Mucha, Juha Alanko, Heikki Vapaatalo

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

We investigated the effects of nicotine and cotinine (0.5 nM-0.5 mM) on prostaglandin E2 and leukotriene B4 production in human polymorphonuclear leukocytes and on thromboxane B2 formation in human platelet-rich plasma, stimulated by calcium ionophore A23187. Nicotine and cotinine dose-dependently increased prostaglandin E2 synthesis in polymorphonuclear leukocytes from 25% (0.5 nM) up to nearly four-fold (0.5 mM). In concentrations found in the plasma of smokers, nicotine and cotinine increased prostaglandin E2 production by 33% (50 nM) and 50% (500 nM), respectively. Nicotine and cotinine equipotentially reduced both leukotriene B4 production in polymorphonuclear leukocytes and thromboxane B2 production in platelet rich plasma, the inhibition increasing from 20% (0.5 nM) to 60% (0.5 mM). The stimulation of prostaglandin E2 and inhibition of leukotriene B4 and thromboxane B2 production by nicotine and cotinine may due to the pyridine moiety that these compounds have in common.

Original languageEnglish
Pages (from-to)345-349
Number of pages5
JournalEuropean Journal of Pharmacology: Environmental Toxicology and
Volume248
Issue number4
DOIs
Publication statusPublished - Dec 1 1993

Keywords

  • Cotinine
  • Leukotrienes
  • Nicotine
  • Prostaglandins
  • Thromboxane

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Pollution

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