Nickel(ii) and mixed metal complexes of amyloid-β N-terminus

Éva Józsa, K. Ősz, C. Kállay, Paolo De Bona, Chiara A. Damante, Giuseppe Pappalardo, Enrico Rizzarelli, I. Sóvágó

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Nickel(ii) complexes of Aβ(1-16)Y10A and its smaller fragments including Aβ(1-4), Aβ(1-6), Ac-Aβ(1-6) and Ac-Aβ(8-16)Y10A have been studied by potentiometric, UV-Vis and circular dichroism spectroscopic measurements. The formation of mixed metal complexes and the distribution of metal ions among the possible coordination sites in the Cu(ii)-Ni(ii)-Aβ(1- 16)Y10A and Cu(ii)-Ni(ii)-Zn(ii)-Aβ(1-16)Y10A systems have also been evaluated. It was found that the hexadecapeptide and its fragments are effective nickel(ii) binding ligands and complex formation processes of nickel(ii) ions are quite similar to those of copper(ii). Formation of mono- and di-nuclear complexes was detected in the nickel(ii)-Aβ(1-16)Y10A system suggesting the existence of two separated metal binding motifs: the N-terminus and internal histidyl residues. The preference for the coordination at the N-terminus was supported by the spectroscopic measurements but in equilibrium with the metal binding at the internal histidyl sites. Neither zinc(ii) nor nickel(ii) can, however, substitute copper(ii) in the mixed metal complexes of Aβ(1-16)Y10A, but both metal ions are able to alter the distribution of copper(ii) ions among the various binding sites. Both N-terminus (amino and His6) and internal histidyl residues (His13 and His14) can work as dinuclear binding motifs, preferably accommodating copper(II) and zinc(II), respectively, while nickel(ii) can occupy the remaining free coordination sites.

Original languageEnglish
Pages (from-to)7046-7053
Number of pages8
JournalDalton Transactions
Volume39
Issue number30
DOIs
Publication statusPublished - Aug 14 2010

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Coordination Complexes
Nickel
Amyloid
Copper
Metals
Ions
Metal ions
Zinc
Circular Dichroism
Binding Sites
Ligands

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Medicine(all)

Cite this

Nickel(ii) and mixed metal complexes of amyloid-β N-terminus. / Józsa, Éva; Ősz, K.; Kállay, C.; De Bona, Paolo; Damante, Chiara A.; Pappalardo, Giuseppe; Rizzarelli, Enrico; Sóvágó, I.

In: Dalton Transactions, Vol. 39, No. 30, 14.08.2010, p. 7046-7053.

Research output: Contribution to journalArticle

Józsa, É, Ősz, K, Kállay, C, De Bona, P, Damante, CA, Pappalardo, G, Rizzarelli, E & Sóvágó, I 2010, 'Nickel(ii) and mixed metal complexes of amyloid-β N-terminus', Dalton Transactions, vol. 39, no. 30, pp. 7046-7053. https://doi.org/10.1039/c0dt00189a
Józsa, Éva ; Ősz, K. ; Kállay, C. ; De Bona, Paolo ; Damante, Chiara A. ; Pappalardo, Giuseppe ; Rizzarelli, Enrico ; Sóvágó, I. / Nickel(ii) and mixed metal complexes of amyloid-β N-terminus. In: Dalton Transactions. 2010 ; Vol. 39, No. 30. pp. 7046-7053.
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AU - Damante, Chiara A.

AU - Pappalardo, Giuseppe

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AU - Sóvágó, I.

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