Nickel Ion Complexes of Amino Acids and Peptides

Teresa Kowalik-Jankowska, Henryk Kozlowski, E. Farkas, I. Sóvágó

Research output: Chapter in Book/Report/Conference proceedingChapter

22 Citations (Scopus)

Abstract

Thermodynamic and structural characteristics of Ni(II) and Ni(III) complexes with amino acids, amino acid derivatives (including phosphonate, oxime and hydroxamic acids), and peptides are discussed and related to nickel specificity and its basic features for biological functioning. In the simple amino acids the amino nitrogen and carboxylate oxygen chelate metal ions, giving complexes of moderate stability. The two critical amino acids for biological implications of nickel are histidine coordinating by the imidazole moiety and cysteine with its thiol sulfur donor. Both residues are also crucial for binding of Ni(II) in peptides, while simple peptides will coordinate Ni(II) via amino and amide nitrogen donors. Ni(III) is relatively easily obtained by oxidation of Ni(II) complexes. A four-nitrogen donor set (e.g. (NH2, 3×N-)) makes Ni(III) species relatively stable and allows to study this oxidation state under mild conditions. The biological consequences including nickel toxicity and its redox ability are discussed in relation to chemical properties of the respective nickel systems.

Original languageEnglish
Title of host publicationNickel and Its Surprising Impact in Nature
Publisherwiley
Pages63-107
Number of pages45
Volume2
ISBN (Print)9780470028131, 047001671X, 9780470016718
DOIs
Publication statusPublished - Mar 12 2007

Fingerprint

Nickel
Ions
Amino Acids
Peptides
Nitrogen
Hydroxamic Acids
Organophosphonates
Oxidation
Oximes
Thermodynamics
Sulfur
Histidine
Sulfhydryl Compounds
Amides
Chemical properties
Oxidation-Reduction
Metal ions
Cysteine
Toxicity
Metals

Keywords

  • Ni(II) amino acid complexes
  • Ni(II) hydroxamic acids complexes
  • Ni(II) oxime complexes
  • Ni(II) peptide complexes
  • Ni(II) phosphonate complexes
  • Ni(III) peptide complexes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Kowalik-Jankowska, T., Kozlowski, H., Farkas, E., & Sóvágó, I. (2007). Nickel Ion Complexes of Amino Acids and Peptides. In Nickel and Its Surprising Impact in Nature (Vol. 2, pp. 63-107). wiley. https://doi.org/10.1002/9780470028131.ch3

Nickel Ion Complexes of Amino Acids and Peptides. / Kowalik-Jankowska, Teresa; Kozlowski, Henryk; Farkas, E.; Sóvágó, I.

Nickel and Its Surprising Impact in Nature. Vol. 2 wiley, 2007. p. 63-107.

Research output: Chapter in Book/Report/Conference proceedingChapter

Kowalik-Jankowska, T, Kozlowski, H, Farkas, E & Sóvágó, I 2007, Nickel Ion Complexes of Amino Acids and Peptides. in Nickel and Its Surprising Impact in Nature. vol. 2, wiley, pp. 63-107. https://doi.org/10.1002/9780470028131.ch3
Kowalik-Jankowska T, Kozlowski H, Farkas E, Sóvágó I. Nickel Ion Complexes of Amino Acids and Peptides. In Nickel and Its Surprising Impact in Nature. Vol. 2. wiley. 2007. p. 63-107 https://doi.org/10.1002/9780470028131.ch3
Kowalik-Jankowska, Teresa ; Kozlowski, Henryk ; Farkas, E. ; Sóvágó, I. / Nickel Ion Complexes of Amino Acids and Peptides. Nickel and Its Surprising Impact in Nature. Vol. 2 wiley, 2007. pp. 63-107
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