Ni-S(uper)o(xide)D(ismutase) inspired Ni(II)- Amino acid complexes covalently grafted onto merrifield's resin - Synthesis, structure and catalytic activity

Z. Csendes, J. T. Kiss, B. Kutus, P. Sipos, I. Pálinkó

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

In this work the syntheses of covalently grafted Ni(II)-complexes formed with various N- or C-protected amino acid ligands (L-histidine, L-tyrosine, L-cysteine and L-cystine) inspired by the active site of the Ni-SOD enzyme are presented. Merrifield's resin was used as support to mimic the proteomic skeleton of the enzyme. Conditions of the syntheses were altered and the structural features of the substances obtained were studied by infrared spectroscopy. It was found that the preparation of covalently anchored Ni(II)-amino acid complexes was successful in all cases. In many cases the structures of the anchored complexes and the coordinating groups substantially varied upon changing the conditions of the syntheses. The obtained materials were studied by energy dispersive X-ray fluorescence coupled to scanning electron microscope (SEM-EDX). All the covalently anchored materials displayed superoxide dismutase (SOD) activity and some proved to be exceptionally efficient in the biochemical test reaction.

Original languageEnglish
Title of host publicationMaterials Science Forum
Pages1012-1017
Number of pages6
Volume730-732
DOIs
Publication statusPublished - 2013
Event6th International Materials Symposium, Materiais 2011 - Guimaraes, Portugal
Duration: Apr 18 2011Apr 20 2011

Publication series

NameMaterials Science Forum
Volume730-732
ISSN (Print)02555476

Other

Other6th International Materials Symposium, Materiais 2011
CountryPortugal
CityGuimaraes
Period4/18/114/20/11

Fingerprint

resins
amino acids
catalytic activity
Amino acids
Catalyst activity
Resins
inorganic peroxides
Amino Acids
Superoxide Dismutase
enzymes
synthesis
Enzymes
Cystines
Cystine
histidine
tyrosine
cysteine
musculoskeletal system
Histidine
Catalyst supports

Keywords

  • Covalent anchoring
  • FT-IR spectroscopy
  • Merrifield's resin
  • Ni(ii)-amino acid complexes
  • Superoxide dismutase (SOD) activity

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering
  • Mechanics of Materials

Cite this

Ni-S(uper)o(xide)D(ismutase) inspired Ni(II)- Amino acid complexes covalently grafted onto merrifield's resin - Synthesis, structure and catalytic activity. / Csendes, Z.; Kiss, J. T.; Kutus, B.; Sipos, P.; Pálinkó, I.

Materials Science Forum. Vol. 730-732 2013. p. 1012-1017 (Materials Science Forum; Vol. 730-732).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Csendes, Z, Kiss, JT, Kutus, B, Sipos, P & Pálinkó, I 2013, Ni-S(uper)o(xide)D(ismutase) inspired Ni(II)- Amino acid complexes covalently grafted onto merrifield's resin - Synthesis, structure and catalytic activity. in Materials Science Forum. vol. 730-732, Materials Science Forum, vol. 730-732, pp. 1012-1017, 6th International Materials Symposium, Materiais 2011, Guimaraes, Portugal, 4/18/11. https://doi.org/10.4028/www.scientific.net/MSF.730-732.1012
Csendes, Z. ; Kiss, J. T. ; Kutus, B. ; Sipos, P. ; Pálinkó, I. / Ni-S(uper)o(xide)D(ismutase) inspired Ni(II)- Amino acid complexes covalently grafted onto merrifield's resin - Synthesis, structure and catalytic activity. Materials Science Forum. Vol. 730-732 2013. pp. 1012-1017 (Materials Science Forum).
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