New types of α-amylase enzyme-inhibitory polysaccharides from d-glucal

S. Kéki, G. Batta, Ilona Bereczki, Zsolt Fejes, Lajos Nagy, Ágnes Zajácz, L. Kandra, I. Kiricsi, G. Deák, M. Zsuga, P. Herczegh

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We describe the synthesis of new types of α-amylase enzyme-inhibitory polysaccharides obtained by polycondensation of 3,6-Di-O-acetyl-d-glucal followed by deacetylation. The structure of the resulting new polysaccharides containing unique 2,3-unsaturated hexopyranose repeating units were unambiguously determined by NMR and MALDI-TOF MS methods. The deacetylated polysaccharides proved to be a semicompetitive inhibitor of the human salivary amylase enzyme.

Original languageEnglish
Pages (from-to)136-140
Number of pages5
JournalCarbohydrate Polymers
Volume63
Issue number1
DOIs
Publication statusPublished - Jan 18 2006

Fingerprint

Amylases
Polysaccharides
amylases
polysaccharides
Enzymes
enzymes
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Polycondensation
Nuclear magnetic resonance
synthesis
d-glucal
methodology

Keywords

  • Ferrier rearrangement
  • MALDI-TOF MS
  • NMR
  • Polycondensation
  • Unsaturated glycals

ASJC Scopus subject areas

  • Food Science
  • Biochemistry

Cite this

New types of α-amylase enzyme-inhibitory polysaccharides from d-glucal. / Kéki, S.; Batta, G.; Bereczki, Ilona; Fejes, Zsolt; Nagy, Lajos; Zajácz, Ágnes; Kandra, L.; Kiricsi, I.; Deák, G.; Zsuga, M.; Herczegh, P.

In: Carbohydrate Polymers, Vol. 63, No. 1, 18.01.2006, p. 136-140.

Research output: Contribution to journalArticle

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AU - Batta, G.

AU - Bereczki, Ilona

AU - Fejes, Zsolt

AU - Nagy, Lajos

AU - Zajácz, Ágnes

AU - Kandra, L.

AU - Kiricsi, I.

AU - Deák, G.

AU - Zsuga, M.

AU - Herczegh, P.

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