New type bifunctional nitrosoureido derivatives with cytostatic activity

E. Csányi, T. Horváth, E. Király, K. Lapis, L. Kópper

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Several bifunctional nitrosoureido sugar alcohol derivatives were synthesized at the Institute for Drug Research in Budapest. For detailed studies two D,L-threitol derivatives have been selected (GYK1 13 324, GYKI 13485). These compounds were less toxic and more effective than BCNU, the calculated therapeutic index values in a broad scale of transplantable, induced and heterotransplanted tumours were found to be more advantageous than with the referent compound. Both GYKI 13324 and GYKI 13485 exert their curative effect when given orally even in leukaemia types of tumours. Their effect on the blood picture of rats is moderate and of short duration.

Original languageEnglish
Pages (from-to)59-66
Number of pages8
JournalOncology
Volume37
DOIs
Publication statusPublished - 1980

Fingerprint

Cytostatic Agents
Sugar Alcohols
Carmustine
Poisons
Heterografts
Neoplasms
Leukemia
Pharmaceutical Preparations
GYKI 13485
Therapeutics
threitol
GYKI 13324

Keywords

  • BCNU
  • Experimental antitumour effect
  • GYKI 13324
  • GYKI 13485
  • Nitrosoureido derivatives
  • Sugar alcohols

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

New type bifunctional nitrosoureido derivatives with cytostatic activity. / Csányi, E.; Horváth, T.; Király, E.; Lapis, K.; Kópper, L.

In: Oncology, Vol. 37, 1980, p. 59-66.

Research output: Contribution to journalArticle

Csányi, E. ; Horváth, T. ; Király, E. ; Lapis, K. ; Kópper, L. / New type bifunctional nitrosoureido derivatives with cytostatic activity. In: Oncology. 1980 ; Vol. 37. pp. 59-66.
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