New tricyclic prezizaane sesquiterpenoids from agarwood

Yi Ling Yang, Wei Li, Hao Wang, Li Yang, Jing Zhe Yuan, Cai Hong Cai, Hui Qin Chen, Wen Hua Dong, Xu Po Ding, Bei Jiang, Attila Mándi, T. Kurtán, Wen Li Mei, Hao Fu Dai

Research output: Contribution to journalArticle

Abstract

Ten new tricyclic prezizaane types sesquiterpenoids (1−10) were isolated from ethyl ether extract of agarwood originated from Aquilaria sp. Their structures were unambiguously elucidated on the basis of 1D and 2D NMR spectra as well as by HRESIMS data. The absolute configuration of the new prezizaenes 1, 2 and 4 was determined by single-crystal X-ray diffraction, while TDDFT-ECD method was applied for 6. Compounds 4 and 5 displayed significant inhibitory activities toward α-glucosidase with IC50 values of 0.22 and 1.99 mM, respectively.

Original languageEnglish
Article number104301
JournalFitoterapia
Volume138
DOIs
Publication statusPublished - Oct 1 2019

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Keywords

  • Aquilaria sp.
  • Prezizaane
  • Sesquiterpenoid
  • TDDFT-ECD
  • α-Glucosidase inhibitory activity

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Yang, Y. L., Li, W., Wang, H., Yang, L., Yuan, J. Z., Cai, C. H., Chen, H. Q., Dong, W. H., Ding, X. P., Jiang, B., Mándi, A., Kurtán, T., Mei, W. L., & Dai, H. F. (2019). New tricyclic prezizaane sesquiterpenoids from agarwood. Fitoterapia, 138, [104301]. https://doi.org/10.1016/j.fitote.2019.104301