New trends in photobiology. Phage nucleoprotein-psoralen interaction: quantitative characterization of dark and photoreactions

G. Rontó, K. Tóth, S. Gáspár, G. Csik

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

The irradiation of the phage T7 system containing psoralen as photosensitizer causes many processes, each of them leading to phage inactivation. These processes include the UV-induced photoreactions in the phage nucleic acid, and photoreactions in the nucleic acid sensitized by either psoralen or psoralen photobreakdown products. In addition the intercalation of the psoralen molecule itself in the phage nucleic acid as well as the psoralen photobreakdown products cause phage inactivation. Under appropriate experimental conditions these reactions can be studied and characterized separately. The quantitative characteristics (e.g. inactivation cross-section, action spectra and index for dark genotoxicity) are demonstrated for different linear and angular psoralens. Some theoretical and practical consequences of the results obtained are discussed.

Original languageEnglish
Pages (from-to)9-27
Number of pages19
JournalJournal of Photochemistry and Photobiology, B: Biology
Volume12
Issue number1
DOIs
Publication statusPublished - Jan 6 1992

Keywords

  • Genotoxicity
  • UV effect
  • bacteriophage
  • photochemotherapy.
  • phototherapy
  • psoralen

ASJC Scopus subject areas

  • Radiation
  • Radiological and Ultrasound Technology
  • Biophysics
  • Radiology Nuclear Medicine and imaging

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