New technique using [125I]labeled rose bengal for the quantification in blood samples of pipecuronium bromide, a muscle relaxant drug

C. Schopfer, J. ‐F Pittet, E. Tassonyi, A. Benakis

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Abstract

A new technique involving the use of [125I]labeled rose bengal for the quantification of pipecuronium bromide (a muscle relaxant drug) is presented. This technique, which is based on the ability of rose bengal to react with pipecuronium and then form a complex which can be extracted into an organic solvent, involves two steps : the purification and labeling of rose bengal with 125I, and the quantification of pipecuronium. The specific activity of the compound (106 μCi/mg) allows for the quantification of pipecuronium in biological samples at concentrations as low as 5 ng/ml.

Original languageEnglish
Pages (from-to)547-556
Number of pages10
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume29
Issue number5
DOIs
Publication statusPublished - May 1991

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Keywords

  • Iodine‐125
  • Pharmacokinetics
  • Pipecuronium
  • Rose bengal

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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