New technique in optical resolutions

M. Acs, A. Mravik, E. Fogassy, Z. Bocskei

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The present paper illustrates the development of an advanced technique in optical resolution. Both of the amphetamine enantiomers can be obtained by a two-step distillation in nearly quantitative yield without any loss of the resolving agent. It is proved that the second-order interactions (H-bond) are sufficient for separation of enantiomers by distillation.

Original languageEnglish
Pages (from-to)314-320
Number of pages7
JournalChirality
Volume6
Issue number4
DOIs
Publication statusPublished - 1994

Fingerprint

Distillation
Enantiomers
Amphetamine

Keywords

  • amphetamine
  • clathrate
  • distillation method
  • optical activation of bases

ASJC Scopus subject areas

  • Analytical Chemistry
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

New technique in optical resolutions. / Acs, M.; Mravik, A.; Fogassy, E.; Bocskei, Z.

In: Chirality, Vol. 6, No. 4, 1994, p. 314-320.

Research output: Contribution to journalArticle

Acs, M, Mravik, A, Fogassy, E & Bocskei, Z 1994, 'New technique in optical resolutions', Chirality, vol. 6, no. 4, pp. 314-320. https://doi.org/10.1002/chir.530060415
Acs, M. ; Mravik, A. ; Fogassy, E. ; Bocskei, Z. / New technique in optical resolutions. In: Chirality. 1994 ; Vol. 6, No. 4. pp. 314-320.
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