New synthesis of naratriptan

László Poszávácz, Gyula Simig, J. Fetter, Ferenc Bertha

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A new synthesis of N-methyl-3-(1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide (naratriptan, 1a) has been elaborated starting from 1-benzyl-1H-indole-5-carbaldehyde (14b). The 1-benzyl group proved to be an advantageous protecting group in the course of the construction of the ethanesulfonamide and methylpipieridinyl side-chains and it was removed in the last step of the synthesis.{A figure is presented}.

Original languageEnglish
Pages (from-to)713-719
Number of pages7
JournalHeterocycles
Volume68
Issue number4
DOIs
Publication statusPublished - Apr 1 2006

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naratriptan
indole

ASJC Scopus subject areas

  • Organic Chemistry

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Poszávácz, L., Simig, G., Fetter, J., & Bertha, F. (2006). New synthesis of naratriptan. Heterocycles, 68(4), 713-719. https://doi.org/10.3987/COM-06-10670

New synthesis of naratriptan. / Poszávácz, László; Simig, Gyula; Fetter, J.; Bertha, Ferenc.

In: Heterocycles, Vol. 68, No. 4, 01.04.2006, p. 713-719.

Research output: Contribution to journalArticle

Poszávácz, L, Simig, G, Fetter, J & Bertha, F 2006, 'New synthesis of naratriptan', Heterocycles, vol. 68, no. 4, pp. 713-719. https://doi.org/10.3987/COM-06-10670
Poszávácz L, Simig G, Fetter J, Bertha F. New synthesis of naratriptan. Heterocycles. 2006 Apr 1;68(4):713-719. https://doi.org/10.3987/COM-06-10670
Poszávácz, László ; Simig, Gyula ; Fetter, J. ; Bertha, Ferenc. / New synthesis of naratriptan. In: Heterocycles. 2006 ; Vol. 68, No. 4. pp. 713-719.
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