New syntheses towards C-glycosyl type glycomimetics

László Somsák, Éva Bokor, László Juhász, Sándor Kun, László Lázár, Éva Juhász-Tóth, Marietta Tóth

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Glycomimetics are compounds that resemble carbohydrate molecules in their chemical structure and/or biological effect. A large variety of compounds can be designed and synthesized to get glycomimetics, however, C-glycosyl derivatives represent one of the most frequently studied subgroup. In the present survey syntheses of a range of five- and six membered C-glycopyranosyl heterocycles, anhydro-aldimine type compounds, exo-glycals, C-glycosyl styrenes, carbon-sulfur bonded oligosaccharide mimics are described. Some of the C-glycopyranosyl azoles, namely 1,2,4-triazoles and imidazoles belong to the most efficient glucose analog inhibitors of glycogen phosphorylase known to date. Biological studies revealed the therapeutical potential of such inhibitors. Other synthetic derivatives offer versatile possibilities to get further glycomimetics.

Original languageEnglish
Pages (from-to)1159-1175
Number of pages17
JournalPure and Applied Chemistry
Volume91
Issue number7
DOIs
Publication statusPublished - Jul 1 2019

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Keywords

  • C-glycosyl compounds
  • ICS-29
  • anhydro-aldimines
  • cross couplings
  • exo-glycals
  • glycogen phosphorylase
  • glycomimetics
  • inhibitors
  • thiol-ene additions
  • tosylhydrazones

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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