New strategy for the synthesis of large peptides as applied to the C-terminal cysteine-rich 41 amino acid fragment of the mouse agouti protein

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Abstract

In this new convergent peptide synthetic approach the advantages of the Fmoc and Boc techniques are combined. Boc-protected peptide fragments prepared on 2-chlorotrityl resin by Fmoc-technique were coupled sequentially in solution. As an example, the C-terminal (91-131) part of the agouti protein comprising all the 5 disulfide bridges in the original molecule has been synthesized by this method.

Original languageEnglish
Pages (from-to)3293-3296
Number of pages4
JournalTetrahedron Letters
Volume38
Issue number18
DOIs
Publication statusPublished - May 5 1997

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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