New strategy for the synthesis of large peptides as applied to the C-terminal cysteine-rich 41 amino acid fragment of the mouse agouti protein

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Abstract

In this new convergent peptide synthetic approach the advantages of the Fmoc and Boc techniques are combined. Boc-protected peptide fragments prepared on 2-chlorotrityl resin by Fmoc-technique were coupled sequentially in solution. As an example, the C-terminal (91-131) part of the agouti protein comprising all the 5 disulfide bridges in the original molecule has been synthesized by this method.

Original languageEnglish
Pages (from-to)3293-3296
Number of pages4
JournalTetrahedron Letters
Volume38
Issue number18
DOIs
Publication statusPublished - May 5 1997

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Agouti Signaling Protein
Peptide Fragments
Disulfides
Cysteine
Resins
Amino Acids
Peptides
Molecules
mouse nonagouti protein

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

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abstract = "In this new convergent peptide synthetic approach the advantages of the Fmoc and Boc techniques are combined. Boc-protected peptide fragments prepared on 2-chlorotrityl resin by Fmoc-technique were coupled sequentially in solution. As an example, the C-terminal (91-131) part of the agouti protein comprising all the 5 disulfide bridges in the original molecule has been synthesized by this method.",
author = "J{\'o}zsef B{\'o}dit and H. S{\"u}li-Vargha and K. Lud{\'a}nyi and K. V{\'e}key and G. Orosz",
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T1 - New strategy for the synthesis of large peptides as applied to the C-terminal cysteine-rich 41 amino acid fragment of the mouse agouti protein

AU - Bódit, József

AU - Süli-Vargha, H.

AU - Ludányi, K.

AU - Vékey, K.

AU - Orosz, G.

PY - 1997/5/5

Y1 - 1997/5/5

N2 - In this new convergent peptide synthetic approach the advantages of the Fmoc and Boc techniques are combined. Boc-protected peptide fragments prepared on 2-chlorotrityl resin by Fmoc-technique were coupled sequentially in solution. As an example, the C-terminal (91-131) part of the agouti protein comprising all the 5 disulfide bridges in the original molecule has been synthesized by this method.

AB - In this new convergent peptide synthetic approach the advantages of the Fmoc and Boc techniques are combined. Boc-protected peptide fragments prepared on 2-chlorotrityl resin by Fmoc-technique were coupled sequentially in solution. As an example, the C-terminal (91-131) part of the agouti protein comprising all the 5 disulfide bridges in the original molecule has been synthesized by this method.

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JF - Tetrahedron Letters

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