New practical synthesis of Tamsulosin

T. Gizur, E. Fogassy, J. Bálint, G. Egri, J. Törley, Á Demeter, I. Greiner

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1 Citation (Scopus)

Abstract

The medicine called Tamsulosin was produced 25 years ago and since then almost 10 new synthesis route has been known. Each process shows the researchers' workstyle, every year, which mainly differs in the way of separating the enantio-mers. The applied reaction steps also reflect the development over the past 25 years and the new synthesis is influenced by the antecedents. The key-intermediate used in our new method is a racemic secondary amine derivative, which is unknown in the literature before and for resolving it, we worked out a quite advantegeous process. By using an optically active secondary amine, side reactions can be avoided.

Original languageEnglish
Pages (from-to)790-795
Number of pages6
JournalChirality
Volume20
Issue number6
DOIs
Publication statusPublished - Jun 1 2008

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Keywords

  • Diastereomers
  • Enantiomers
  • Optically active amine
  • Resolution

ASJC Scopus subject areas

  • Analytical Chemistry
  • Catalysis
  • Pharmacology
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

Cite this

Gizur, T., Fogassy, E., Bálint, J., Egri, G., Törley, J., Demeter, Á., & Greiner, I. (2008). New practical synthesis of Tamsulosin. Chirality, 20(6), 790-795. https://doi.org/10.1002/chir.20544