A statinok alkalmazásának lehetséges új területei

Translated title of the contribution: New potential perspectives of statin therapy

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Statins have become crucial components of the therapy of cardiovascular diseases. Beyond their cholesterol-lowering effect, statins turned out to have further beneficial effects on various vascular mechanisms. One of the best known effects is antithrombotic capacity, which is related partly to platelet function and partly to the coagulation cascade. Besides experimental observations, interventional clinical trials have also demonstrated that statins have an antithrombotic effect both in arterial and venous thrombosis. Regarding the effects of statins on dementia, previous studies with relatively small sample sizes had controversial results. Recently, two observational studies of tens of thousands of elderly patients reported that statins reduce the incidence of nonvascular dementia. Evaluation of the data revealed that statins have pleiotropic effects in this case, too. The results discussed here shed light on new benefits of statin therapy used for reducing cardiovascular mortality, namely the prevention of thrombotic events and dementia. These benefits are related to the antithrombotic and anti-inflammatoric capacity of statins.

Translated title of the contributionNew potential perspectives of statin therapy
Original languageHungarian
Pages (from-to)599-603
Number of pages5
JournalLege Artis Medicinae
Volume23
Issue number12
Publication statusPublished - Dec 1 2013

ASJC Scopus subject areas

  • Medicine(all)

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