New potent P-glycoprotein inhibitors carrying a polycyclic scaffold

Alessandra Bisi, Silvia Gobbi, Angela Rampa, Federica Belluti, Lorna Piazzi, Piero Valenti, N. Gyémánt, J. Molnár

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

New pentacyclic inhibitors of the P-glycoprotein carrying nitrogen-containing alkyl chains were synthesized and evaluated for MDR reverting activity on mouse lymphoma cells infected with pHa MDR1/A retrovirus. The activity of the compounds proved to be up to 5-fold higher than verapamil, used as reference compound.

Original languageEnglish
Pages (from-to)3049-3051
Number of pages3
JournalJournal of Medicinal Chemistry
Volume49
Issue number11
DOIs
Publication statusPublished - Jun 1 2006

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P-Glycoprotein
Retroviridae
Verapamil
Scaffolds
Lymphoma
Nitrogen

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Bisi, A., Gobbi, S., Rampa, A., Belluti, F., Piazzi, L., Valenti, P., ... Molnár, J. (2006). New potent P-glycoprotein inhibitors carrying a polycyclic scaffold. Journal of Medicinal Chemistry, 49(11), 3049-3051. https://doi.org/10.1021/jm060056p

New potent P-glycoprotein inhibitors carrying a polycyclic scaffold. / Bisi, Alessandra; Gobbi, Silvia; Rampa, Angela; Belluti, Federica; Piazzi, Lorna; Valenti, Piero; Gyémánt, N.; Molnár, J.

In: Journal of Medicinal Chemistry, Vol. 49, No. 11, 01.06.2006, p. 3049-3051.

Research output: Contribution to journalArticle

Bisi, A, Gobbi, S, Rampa, A, Belluti, F, Piazzi, L, Valenti, P, Gyémánt, N & Molnár, J 2006, 'New potent P-glycoprotein inhibitors carrying a polycyclic scaffold', Journal of Medicinal Chemistry, vol. 49, no. 11, pp. 3049-3051. https://doi.org/10.1021/jm060056p
Bisi A, Gobbi S, Rampa A, Belluti F, Piazzi L, Valenti P et al. New potent P-glycoprotein inhibitors carrying a polycyclic scaffold. Journal of Medicinal Chemistry. 2006 Jun 1;49(11):3049-3051. https://doi.org/10.1021/jm060056p
Bisi, Alessandra ; Gobbi, Silvia ; Rampa, Angela ; Belluti, Federica ; Piazzi, Lorna ; Valenti, Piero ; Gyémánt, N. ; Molnár, J. / New potent P-glycoprotein inhibitors carrying a polycyclic scaffold. In: Journal of Medicinal Chemistry. 2006 ; Vol. 49, No. 11. pp. 3049-3051.
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