New plasmid curing compounds. anthril and phenathril derivatives

J. Molnár, Sandor Földeak, Peter Hegyes, Bela Schneider, Ian B. Holland

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The plasmid curing activities of some newly synthesized tricyclic compounds has been studied. Anthracene was substituted at the 1st, 2nd or 9th carbon atom with acetyl-, dimethylamino-propanone, dimethylaminpropanol or dimethylaminopropene radicals. Derivatives of phenathrene similarly substituted at the 9-postition were also synthesized. All the dimethyl-aminopropanol substituted anthril- and phenanthril-derivatives showed significant curing effects on the E. coli K12 strain carrying an F'lac-plasmid. The most effective compounds were the symmetrically substituted 9-anthril- and 9-phenanthril derivatives producing 25-40 per cent cured clones under the standard conditions. Disruption of the π-electron system of the three rings caused a significant decrease in the plasmid curing effect of 9-substituted anthracene.

Original languageEnglish
Pages (from-to)261-265
Number of pages5
JournalBiochemical Pharmacology
Volume28
Issue number2
DOIs
Publication statusPublished - 1979

Fingerprint

Curing
Propanolamines
Plasmids
F Factor
Derivatives
Escherichia coli K12
Carbon
Clone Cells
Electrons
Escherichia coli
Atoms
anthracene

ASJC Scopus subject areas

  • Pharmacology

Cite this

New plasmid curing compounds. anthril and phenathril derivatives. / Molnár, J.; Földeak, Sandor; Hegyes, Peter; Schneider, Bela; Holland, Ian B.

In: Biochemical Pharmacology, Vol. 28, No. 2, 1979, p. 261-265.

Research output: Contribution to journalArticle

Molnár, J. ; Földeak, Sandor ; Hegyes, Peter ; Schneider, Bela ; Holland, Ian B. / New plasmid curing compounds. anthril and phenathril derivatives. In: Biochemical Pharmacology. 1979 ; Vol. 28, No. 2. pp. 261-265.
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