New planar liquid chromatographic technique: overpressured thin-layer chromatography

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Abstract

A novel planar liquid chromatographic technique using a pressurized ultramicro chamber (PUM chamber) has been developed. The sorbent layer is completely covered by a membrane under external pressure, so that the vapour phase above the layer is virtually eliminated. Solvent is admitted under pressure by means of a pump system. The main advantage of this technique, termed overpressured thin-layer chromatography (TLC), is the substantially shorter time required for separation than in classical column chromatography and TLC, with velocities of the mobile phase about as stable as in high-performance liquid chromatography, and aggressive reagents being applicable as in classical TLC. The method appears to be suitable for the accurate modelling of column chromatographic methods.

Original languageEnglish
Pages (from-to)75-81
Number of pages7
JournalJournal of Chromatography A
Volume174
Issue number1
DOIs
Publication statusPublished - Jun 1 1979

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Thin layer chromatography
Thin Layer Chromatography
Liquids
Vapor Pressure
Column chromatography
High performance liquid chromatography
Sorbents
Chromatography
Vapors
High Pressure Liquid Chromatography
Pumps
Membranes
Pressure

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

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abstract = "A novel planar liquid chromatographic technique using a pressurized ultramicro chamber (PUM chamber) has been developed. The sorbent layer is completely covered by a membrane under external pressure, so that the vapour phase above the layer is virtually eliminated. Solvent is admitted under pressure by means of a pump system. The main advantage of this technique, termed overpressured thin-layer chromatography (TLC), is the substantially shorter time required for separation than in classical column chromatography and TLC, with velocities of the mobile phase about as stable as in high-performance liquid chromatography, and aggressive reagents being applicable as in classical TLC. The method appears to be suitable for the accurate modelling of column chromatographic methods.",
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