New Perspectives for Anatomical and Molecular Studies of Kisspeptin Neurons in the Aging Human Brain

Erik Hrabovszky, Szabolcs Takács, Balázs Göcz, Katalin Skrapits

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The human infundibular nucleus (corresponding to the rodent arcuate nucleus) serves as an important integration center for neuronal signals and hormones released by peripheral endocrine organs. Kisspeptin (KP)-producing neurons of this anatomical site, many of which also synthesize neurokinin B (NKB), are critically involved in sex hormone signaling to gonadotropin-releasing hormone (GnRH) neurons. In recent years, the basic topography, morphology, neuropeptide content, and connectivity of human KP neurons have been investigated with in situ hybridization and immunohistochemistry on postmortem tissues. These studies revealed that human KP neurons differ neurochemically from their rodent counterparts and show robust aging-related plasticity. Earlier immunohistochemical experiments also provided evidence for temporal changes in the hypothalamus of aging men whose NKB and KP neurons undergo hypertrophy, increase in number, exhibit increased neuropeptide mRNA expression and immunoreactivity and give rise to higher numbers of immunoreactive fibers and afferent contacts onto GnRH neurons. Increasing percentages of KP-expressing NKB perikarya, NKB axons, and NKB inputs to GnRH neurons raise the intriguing possibility that a significant subset of NKB neurons begins to cosynthesize KP as aging advances. Although use of postmortem tissues is technically challenging, recently available single-cell anatomical and molecular approaches discussed in this review provide promising new tools to investigate the aging-related anatomical and functional plasticity of the human KP neuronal system.

Original languageEnglish
Pages (from-to)230-241
Number of pages12
JournalNeuroendocrinology
Volume109
Issue number3
DOIs
Publication statusPublished - Sep 1 2019

Keywords

  • Gonadotropin-releasing hormone
  • Hypothalamus
  • Immunohistochemistry
  • Kisspeptin
  • LHRH
  • Neurokinin B
  • Reproduction

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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