New method for preparation of delivery systems of poorly soluble drugs on the basis of functionalized mesoporous MCM-41 nanoparticles

M. Popova, A. Szegedi, K. Yoncheva, S. Konstantinov, G. P. Petrova, H. A. Aleksandrov, G. N. Vayssilov, P. Shestakova

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

MCM-41 silica with spherical morphology and small particle sizes (100 nm) was synthesized and modified by post-synthesis method with amino and/or carboxylic groups. Solid state reaction was applied for the first time for loading of poorly soluble drug mesalazine (5-aminosalicylic acid - 5-ASA). The non-loaded and drug loaded mesoporous silicas were characterized by XRD, TEM, N2 physisorption, elemental analysis, thermal analysis, FT-IR and solid state NMR spectroscopy. Quantum-chemical calculations were used to predict the interactions between the drug molecule and the functional groups of the carrier. The nanoparticles were post-coated with sodium alginate and the coating modified the rate of mesalazine release from MCM-41NH2 and MCM-41NH2COOH particles. Cytotoxic evaluation on colon adenocarcinoma cell line revealed that the alginate coating reduced cytotoxicity of mesalazine loaded in the post-coated particles compared to the pure mesalazine. The functionalized, polymer coated mesoporous systems are suitable oral drug delivery systems providing an opportunity to modify drug release.

Original languageEnglish
Pages (from-to)247-255
Number of pages9
JournalMicroporous and Mesoporous Materials
Volume198
DOIs
Publication statusPublished - Nov 1 2014

Fingerprint

Mesalamine
Multicarrier modulation
delivery
drugs
Nanoparticles
nanoparticles
preparation
Silica
Pharmaceutical Preparations
Sodium alginate
Coatings
Physisorption
Silicon Dioxide
Alginate
Cytotoxicity
Solid state reactions
Thermoanalysis
Functional groups
Nuclear magnetic resonance spectroscopy
silicon dioxide

Keywords

  • Alginate coating
  • Mesalazine release
  • Solid-state reaction
  • Spherical MCM-41

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Chemistry(all)
  • Condensed Matter Physics

Cite this

New method for preparation of delivery systems of poorly soluble drugs on the basis of functionalized mesoporous MCM-41 nanoparticles. / Popova, M.; Szegedi, A.; Yoncheva, K.; Konstantinov, S.; Petrova, G. P.; Aleksandrov, H. A.; Vayssilov, G. N.; Shestakova, P.

In: Microporous and Mesoporous Materials, Vol. 198, 01.11.2014, p. 247-255.

Research output: Contribution to journalArticle

Popova, M. ; Szegedi, A. ; Yoncheva, K. ; Konstantinov, S. ; Petrova, G. P. ; Aleksandrov, H. A. ; Vayssilov, G. N. ; Shestakova, P. / New method for preparation of delivery systems of poorly soluble drugs on the basis of functionalized mesoporous MCM-41 nanoparticles. In: Microporous and Mesoporous Materials. 2014 ; Vol. 198. pp. 247-255.
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