New metabolic influencer on oxytocin release: The ghrelin

Renáta Szabó, Rudolf Ménesi, A. Molnár, Zita Szalai, Lejla Daruka, G. Tóth, J. Gardi, M. Gálfi, Denise Börzsei, Krisztina Kupai, Anna Juhász, Marianna Radács, F. László, C. Varga, A. Pósa

Research output: Contribution to journalArticle

Abstract

Background: The hypothalamic–pituitary axis by secreting neuropeptides plays a key role in metabolic homeostasis. In light of the metabolic regulation, oxytocin is a potential neuropeptide for therapies against obesity and related disorders. The aim of our study is to measure ghrelin-induced oxytocin secretion in rats and to detect the changes after administration of ghrelin antagonist. Methods: Ghrelin was administrated centrally (intracerebroventricular, i.c.v., 1.0, 10.0, and 100.0 pmol) or systemically (intravenous, i.v., 1.0, and 10.0 nmol). [D-Lys 3 ]-GHRP-6 ghrelin antagonist was injected 15 min before ghrelin injection in a dose of 10.0 pmol i.c.v. and 10.0 nmol i.v. Results: Either i.c.v. or i.v. administration of ghrelin dose-dependently increased the plasma oxytocin concentration. Following pretreatment with the ghrelin antagonist [D-Lys 3 ]-GHRP-6, the high plasma oxytocin level induced by ghrelin was significantly reduced. Conclusion: The results indicate that the release of oxytocin is influenced directly by the ghrelin system. Examination of the mechanism of ghrelin-induced oxytocin secretion is a new horizon for potential therapeutic options.

Original languageEnglish
Article number735
JournalMolecules
Volume24
Issue number4
DOIs
Publication statusPublished - Feb 18 2019

Fingerprint

secretions
Ghrelin
Oxytocin
obesity
homeostasis
dosage
pretreatment
rats
horizon
therapy
examination
disorders
injection
Neuropeptides
Plasmas
Rats
Homeostasis
Obesity

Keywords

  • Ghrelin
  • Ghrelin antagonist
  • Neuropeptide regulation
  • Oxytocin

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

New metabolic influencer on oxytocin release : The ghrelin. / Szabó, Renáta; Ménesi, Rudolf; Molnár, A.; Szalai, Zita; Daruka, Lejla; Tóth, G.; Gardi, J.; Gálfi, M.; Börzsei, Denise; Kupai, Krisztina; Juhász, Anna; Radács, Marianna; László, F.; Varga, C.; Pósa, A.

In: Molecules, Vol. 24, No. 4, 735, 18.02.2019.

Research output: Contribution to journalArticle

Szabó, R, Ménesi, R, Molnár, A, Szalai, Z, Daruka, L, Tóth, G, Gardi, J, Gálfi, M, Börzsei, D, Kupai, K, Juhász, A, Radács, M, László, F, Varga, C & Pósa, A 2019, 'New metabolic influencer on oxytocin release: The ghrelin', Molecules, vol. 24, no. 4, 735. https://doi.org/10.3390/molecules24040735
Szabó, Renáta ; Ménesi, Rudolf ; Molnár, A. ; Szalai, Zita ; Daruka, Lejla ; Tóth, G. ; Gardi, J. ; Gálfi, M. ; Börzsei, Denise ; Kupai, Krisztina ; Juhász, Anna ; Radács, Marianna ; László, F. ; Varga, C. ; Pósa, A. / New metabolic influencer on oxytocin release : The ghrelin. In: Molecules. 2019 ; Vol. 24, No. 4.
@article{077cfcb49ba645deac222054e32dd903,
title = "New metabolic influencer on oxytocin release: The ghrelin",
abstract = "Background: The hypothalamic–pituitary axis by secreting neuropeptides plays a key role in metabolic homeostasis. In light of the metabolic regulation, oxytocin is a potential neuropeptide for therapies against obesity and related disorders. The aim of our study is to measure ghrelin-induced oxytocin secretion in rats and to detect the changes after administration of ghrelin antagonist. Methods: Ghrelin was administrated centrally (intracerebroventricular, i.c.v., 1.0, 10.0, and 100.0 pmol) or systemically (intravenous, i.v., 1.0, and 10.0 nmol). [D-Lys 3 ]-GHRP-6 ghrelin antagonist was injected 15 min before ghrelin injection in a dose of 10.0 pmol i.c.v. and 10.0 nmol i.v. Results: Either i.c.v. or i.v. administration of ghrelin dose-dependently increased the plasma oxytocin concentration. Following pretreatment with the ghrelin antagonist [D-Lys 3 ]-GHRP-6, the high plasma oxytocin level induced by ghrelin was significantly reduced. Conclusion: The results indicate that the release of oxytocin is influenced directly by the ghrelin system. Examination of the mechanism of ghrelin-induced oxytocin secretion is a new horizon for potential therapeutic options.",
keywords = "Ghrelin, Ghrelin antagonist, Neuropeptide regulation, Oxytocin",
author = "Ren{\'a}ta Szab{\'o} and Rudolf M{\'e}nesi and A. Moln{\'a}r and Zita Szalai and Lejla Daruka and G. T{\'o}th and J. Gardi and M. G{\'a}lfi and Denise B{\"o}rzsei and Krisztina Kupai and Anna Juh{\'a}sz and Marianna Rad{\'a}cs and F. L{\'a}szl{\'o} and C. Varga and A. P{\'o}sa",
year = "2019",
month = "2",
day = "18",
doi = "10.3390/molecules24040735",
language = "English",
volume = "24",
journal = "Molecules",
issn = "1420-3049",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "4",

}

TY - JOUR

T1 - New metabolic influencer on oxytocin release

T2 - The ghrelin

AU - Szabó, Renáta

AU - Ménesi, Rudolf

AU - Molnár, A.

AU - Szalai, Zita

AU - Daruka, Lejla

AU - Tóth, G.

AU - Gardi, J.

AU - Gálfi, M.

AU - Börzsei, Denise

AU - Kupai, Krisztina

AU - Juhász, Anna

AU - Radács, Marianna

AU - László, F.

AU - Varga, C.

AU - Pósa, A.

PY - 2019/2/18

Y1 - 2019/2/18

N2 - Background: The hypothalamic–pituitary axis by secreting neuropeptides plays a key role in metabolic homeostasis. In light of the metabolic regulation, oxytocin is a potential neuropeptide for therapies against obesity and related disorders. The aim of our study is to measure ghrelin-induced oxytocin secretion in rats and to detect the changes after administration of ghrelin antagonist. Methods: Ghrelin was administrated centrally (intracerebroventricular, i.c.v., 1.0, 10.0, and 100.0 pmol) or systemically (intravenous, i.v., 1.0, and 10.0 nmol). [D-Lys 3 ]-GHRP-6 ghrelin antagonist was injected 15 min before ghrelin injection in a dose of 10.0 pmol i.c.v. and 10.0 nmol i.v. Results: Either i.c.v. or i.v. administration of ghrelin dose-dependently increased the plasma oxytocin concentration. Following pretreatment with the ghrelin antagonist [D-Lys 3 ]-GHRP-6, the high plasma oxytocin level induced by ghrelin was significantly reduced. Conclusion: The results indicate that the release of oxytocin is influenced directly by the ghrelin system. Examination of the mechanism of ghrelin-induced oxytocin secretion is a new horizon for potential therapeutic options.

AB - Background: The hypothalamic–pituitary axis by secreting neuropeptides plays a key role in metabolic homeostasis. In light of the metabolic regulation, oxytocin is a potential neuropeptide for therapies against obesity and related disorders. The aim of our study is to measure ghrelin-induced oxytocin secretion in rats and to detect the changes after administration of ghrelin antagonist. Methods: Ghrelin was administrated centrally (intracerebroventricular, i.c.v., 1.0, 10.0, and 100.0 pmol) or systemically (intravenous, i.v., 1.0, and 10.0 nmol). [D-Lys 3 ]-GHRP-6 ghrelin antagonist was injected 15 min before ghrelin injection in a dose of 10.0 pmol i.c.v. and 10.0 nmol i.v. Results: Either i.c.v. or i.v. administration of ghrelin dose-dependently increased the plasma oxytocin concentration. Following pretreatment with the ghrelin antagonist [D-Lys 3 ]-GHRP-6, the high plasma oxytocin level induced by ghrelin was significantly reduced. Conclusion: The results indicate that the release of oxytocin is influenced directly by the ghrelin system. Examination of the mechanism of ghrelin-induced oxytocin secretion is a new horizon for potential therapeutic options.

KW - Ghrelin

KW - Ghrelin antagonist

KW - Neuropeptide regulation

KW - Oxytocin

UR - http://www.scopus.com/inward/record.url?scp=85061565427&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061565427&partnerID=8YFLogxK

U2 - 10.3390/molecules24040735

DO - 10.3390/molecules24040735

M3 - Article

C2 - 30781678

AN - SCOPUS:85061565427

VL - 24

JO - Molecules

JF - Molecules

SN - 1420-3049

IS - 4

M1 - 735

ER -