New metabolic influencer on oxytocin release: The ghrelin

Renáta Szabó, Rudolf Ménesi, Andor H. Molnár, Zita Szalai, Lejla Daruka, Gábor Tóth, János Gardi, Márta Gálfi, Denise Börzsei, Krisztina Kupai, A. Juhász, Marianna Radács, Ferenc A. László, Csaba Varga, Anikó Pósa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: The hypothalamic–pituitary axis by secreting neuropeptides plays a key role in metabolic homeostasis. In light of the metabolic regulation, oxytocin is a potential neuropeptide for therapies against obesity and related disorders. The aim of our study is to measure ghrelin-induced oxytocin secretion in rats and to detect the changes after administration of ghrelin antagonist. Methods: Ghrelin was administrated centrally (intracerebroventricular, i.c.v., 1.0, 10.0, and 100.0 pmol) or systemically (intravenous, i.v., 1.0, and 10.0 nmol). [D-Lys3]-GHRP-6 ghrelin antagonist was injected 15 min before ghrelin injection in a dose of 10.0 pmol i.c.v. and 10.0 nmol i.v. Results: Either i.c.v. or i.v. administration of ghrelin dose-dependently increased the plasma oxytocin concentration. Following pretreatment with the ghrelin antagonist [D-Lys3]-GHRP-6, the high plasma oxytocin level induced by ghrelin was significantly reduced. Conclusion: The results indicate that the release of oxytocin is influenced directly by the ghrelin system. Examination of the mechanism of ghrelin-induced oxytocin secretion is a new horizon for potential therapeutic options.

Original languageEnglish
Article number735
JournalMolecules
Volume24
Issue number4
DOIs
Publication statusPublished - Feb 18 2019

Keywords

  • Ghrelin
  • Ghrelin antagonist
  • Neuropeptide regulation
  • Oxytocin

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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