New insights into the chemical profiling, cytotoxicity and bioactivity of four Bunium species

Gokhan Zengin, Mehmet Yavuz Paksoy, Muhammad Zakariyyah Aumeeruddy, Jasmina Glamocilja, Marina Sokovic, Alina Diuzheva, J. Jekó́, Zoltán Cziáky, Maria João Rodrigues, Luisa Custodio, Mohamad Fawzi Mahomoodally

Research output: Contribution to journalArticle

Abstract

Bunium species have been reported to be used both as food and in traditional medicines. The scientific community has attempted to probe into the pharmacological and chemical profiles of this genus. Nonetheless, many species have not been investigated fully to date. In this study, we determined the phenolic components, antimicrobial, antioxidant, and enzyme inhibitory activities of aerial parts of four Bunium species (B. sayai, B. pinnatifolium, B. brachyactis and B. macrocarpum). Results showed that B. microcarpum and B. pinnatifolium were strong antioxidants as evidenced in the DPPH, ABTS, CUPRAC, and FRAP assays. B. brachyactis was the most effective metal chelator, and displayed high enzyme inhibition against cholinesterase, tyrosinase, amylase, glucosidase, and lipase. The four species showed varied antimicrobial activity against each microorganism. Overall, they showed high activity against P. mirabilis and E. coli (MIC and MBC <1 mg mL −1 ). B. brachyactis was more effective against Aspergillus versicolor compared to the standard drug ketoconazole. B. brachyactis was also more effective than both ketoconazole and bifonazole against Trichoderma viride. B. sayai was more effective than ketoconazole in inhibiting A. fumigatus. B. sayai was most non-toxic to HEK 293 (cellular viability = 117%) and HepG2 (cellular viability = 104%). The highest level of TPC was observed in B. pinnatifolium (35.94 mg GAE g −1 ) while B. microcarpum possessed the highest TFC (39.21 mg RE g −1 ). Seventy four compounds were detected in B. microcarpum, 70 in B. brachyactis, 66 in B. sayai, and 51 in B. pinnatifolium. Quinic acid, chlorogenic acid, pantothenic acid, esculin, isoquercitrin, rutin, apigenin, and scopoletin were present in all the four species. This study showed that the four Bunium species are good sources of biologically active compounds with pharmaceutical and nutraceutical potential.

Original languageEnglish
Pages (from-to)414-424
Number of pages11
JournalFood Research International
Volume123
DOIs
Publication statusPublished - Sep 1 2019

Fingerprint

Bunium
ketoconazole
Ketoconazole
cytotoxicity
bifonazole
Antioxidants
anti-infective agents
Esculin
Scopoletin
Quinic Acid
Mirabilis
viability
Aspergillus versicolor
isoquercitrin
Pantothenic Acid
Glucosidases
Apigenin
antioxidants
scopoletin
Chlorogenic Acid

Keywords

  • antioxidant
  • Bunium
  • cytotoxicity
  • enzyme inhibitors
  • phytoconstituents

ASJC Scopus subject areas

  • Food Science

Cite this

Zengin, G., Paksoy, M. Y., Aumeeruddy, M. Z., Glamocilja, J., Sokovic, M., Diuzheva, A., ... Mahomoodally, M. F. (2019). New insights into the chemical profiling, cytotoxicity and bioactivity of four Bunium species. Food Research International, 123, 414-424. https://doi.org/10.1016/j.foodres.2019.05.013

New insights into the chemical profiling, cytotoxicity and bioactivity of four Bunium species. / Zengin, Gokhan; Paksoy, Mehmet Yavuz; Aumeeruddy, Muhammad Zakariyyah; Glamocilja, Jasmina; Sokovic, Marina; Diuzheva, Alina; Jekó́, J.; Cziáky, Zoltán; Rodrigues, Maria João; Custodio, Luisa; Mahomoodally, Mohamad Fawzi.

In: Food Research International, Vol. 123, 01.09.2019, p. 414-424.

Research output: Contribution to journalArticle

Zengin, G, Paksoy, MY, Aumeeruddy, MZ, Glamocilja, J, Sokovic, M, Diuzheva, A, Jekó́, J, Cziáky, Z, Rodrigues, MJ, Custodio, L & Mahomoodally, MF 2019, 'New insights into the chemical profiling, cytotoxicity and bioactivity of four Bunium species', Food Research International, vol. 123, pp. 414-424. https://doi.org/10.1016/j.foodres.2019.05.013
Zengin, Gokhan ; Paksoy, Mehmet Yavuz ; Aumeeruddy, Muhammad Zakariyyah ; Glamocilja, Jasmina ; Sokovic, Marina ; Diuzheva, Alina ; Jekó́, J. ; Cziáky, Zoltán ; Rodrigues, Maria João ; Custodio, Luisa ; Mahomoodally, Mohamad Fawzi. / New insights into the chemical profiling, cytotoxicity and bioactivity of four Bunium species. In: Food Research International. 2019 ; Vol. 123. pp. 414-424.
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