New in vitro line from a human (B) non-Hodgkin lymphoma

L. Kópper, A. Bankfalvi, R. Mihalik, P. Nagy, C. Fulop, G. Sármay

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

An in vitro cell line (HT 58) has been established from a human (B) NHL xenograft. The lymphoma cells in culture retained their lymphblastic appearance, DNA-content, IgM/lambda monoclonality and many immunophenotypic markers. The clonal chromosomal abnormalities involved the chromosomes 1, 2, 3 and 14. The cells expressed and produced chondroitin sulfate proteoglycans identified with mAbs that were raised against human articular cartilage CSPG. The cells also released IgM into the medium as well as substances that stimulated the proliferation of activated normal peripheral B-cells.

Original languageEnglish
Pages (from-to)1645-1649
Number of pages5
JournalAnticancer Research
Volume11
Issue number4
Publication statusPublished - 1991

Fingerprint

Non-Hodgkin's Lymphoma
Immunoglobulin M
Chondroitin Sulfate Proteoglycans
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 2
Chromosomes, Human, Pair 1
Articular Cartilage
Heterografts
Chromosome Aberrations
Lymphoma
B-Lymphocytes
Cell Culture Techniques
Cell Line
DNA
In Vitro Techniques

Keywords

  • Cell line
  • Human
  • Non-Hodgkin lymphoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

New in vitro line from a human (B) non-Hodgkin lymphoma. / Kópper, L.; Bankfalvi, A.; Mihalik, R.; Nagy, P.; Fulop, C.; Sármay, G.

In: Anticancer Research, Vol. 11, No. 4, 1991, p. 1645-1649.

Research output: Contribution to journalArticle

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AU - Sármay, G.

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