New gas chromatographic method for the enantioseparation of β-amino acids by a rapid double derivatization technique

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33 Citations (Scopus)

Abstract

A novel gas chromatographic method was developed for the enantioseparation of valuable acyclic and carbocyclic cis- and trans-β-amino acids, including cispentacin and a number of its analogues and homologues. Excellent (in most cases baseline) separation was achieved for the racemates of these β-amino acids on CP-Chirasil-Dex CB or CP-Chirasil L-Val columns after a simple and rapid double derivatization (esterification followed by N-acylation). The elution sequences were determined in all cases.

Original languageEnglish
Pages (from-to)1025-1029
Number of pages5
JournalJournal of Chromatography A
Volume1216
Issue number6
DOIs
Publication statusPublished - Feb 6 2009

Keywords

  • Cispentacin
  • Double derivatization
  • Enantiomeric separation
  • Gas chromatography
  • β-Amino acids

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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