New fluorescent isoquinoline derivatives

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Abstract

Various structural modifications of 3-amino and 3-hydroxyisoquinolines have been carried out to provide new fluorescent derivatives. The transformations involved nucleophilic substitution of a bromine atom or a triflate moiety at positions 1 and 3, respectively, as well as the condensation reaction of a 3-amino group with triethyl orthoformate and subsequent transformation with amines to give amidines. The new compounds have been studied by fluorescence spectroscopy.

Original languageEnglish
Pages (from-to)5264-5266
Number of pages3
JournalTetrahedron Letters
Volume52
Issue number41
DOIs
Publication statusPublished - Oct 12 2011

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Keywords

  • Amidine
  • Fluorescence spectrum
  • Formimidate
  • Isoquinoline-amine
  • Quantum yield

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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