New ferrocene containing peptide conjugates: Synthesis and effect on human leukemia (HL-60) cells

Zsanett Miklán, Rita Szabó, Virág Zsoldos-Mády, Judit Reményi, Z. Bánóczi, F. Hudecz

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Data reported in this article describe the synthesis of Arg-rich oligopeptide conjugates of ferrocenecarboxylic acid on solid support with two different strategies and for the first time, the successful preparation of peptide conjugates of ferrocenylacrylic acid in solution. The antitumor effect of conjugates was analyzed by MTT assay in vitro. We demonstrated that ferrocenylacrylic acid possessing an enone (-CH=CH-CO-) moiety exhibited remarkable antiproliferative effect against human leukemia cells (HL-60) in vitro, but its effect was not improved by conjugation with hexa- or octaarginines. However, we observed highly increased water-solubility. In contrast, the results provide evidence that conjugation of ferrocenecarboxylic acid to Argn (n = 6, 8) improved not only its water-solubility, but also antitumor effect on human leukemia cells in vitro.

Original languageEnglish
Pages (from-to)108-114
Number of pages7
JournalBiopolymers - Peptide Science Section
Volume88
Issue number2
DOIs
Publication statusPublished - 2007

Fingerprint

HL-60 Cells
Peptides
Leukemia
Solubility
Oligopeptides
Acids
Water
Carbon Monoxide
Assays
ferrocene
In Vitro Techniques
ferrocenecarboxylic acid
octaarginine

Keywords

  • Ferrocene derivatives
  • In vitro cytostatic activity on HL-60 cells
  • Oligoarginine conjugates
  • Synthesis of ferrocene conjugates

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biophysics

Cite this

New ferrocene containing peptide conjugates : Synthesis and effect on human leukemia (HL-60) cells. / Miklán, Zsanett; Szabó, Rita; Zsoldos-Mády, Virág; Reményi, Judit; Bánóczi, Z.; Hudecz, F.

In: Biopolymers - Peptide Science Section, Vol. 88, No. 2, 2007, p. 108-114.

Research output: Contribution to journalArticle

Miklán, Zsanett ; Szabó, Rita ; Zsoldos-Mády, Virág ; Reményi, Judit ; Bánóczi, Z. ; Hudecz, F. / New ferrocene containing peptide conjugates : Synthesis and effect on human leukemia (HL-60) cells. In: Biopolymers - Peptide Science Section. 2007 ; Vol. 88, No. 2. pp. 108-114.
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AU - Bánóczi, Z.

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