A haemolyticus uraemias szindroma uj vonatkozasai

Translated title of the contribution: New developments in haemolytic uraemic syndrome

Research output: Contribution to journalArticle

Abstract

Haemolytic uraemic syndrome is the major cause of acute renal failure in childhood and one of the severest multiorgan disease of adults. The three main forms of the disease are 1. typical, diarrhoea-associated (D+) haemolytic uraemic syndrome; 2. atypical, sporadic (D-) form; 3. thrombotic thrombocytopenic purpura. The D+ form has got a homogenous aetiology of verotoxin producing E. coli O157:H7 or Shigella dysenteriae infections with a rapid onset and synchronous manifestation of the main clinical symptoms (uraemia, haemolysis, thrombocytopenia), while prognosis is good. The D- form has got no prodrome of a bloody diarrhoea, and appears with an asynchronous manifestation of the clinical symptoms, while the outcome is frequently poor. Thrombotic thrombocytopenic purpura is very similar to D- haemolytic uraemic syndrome and is associated with multiplex purpuras. Histologically in young children only glomerular changes, while in elder children and adults rather arteriolar damage or both are present. The treatment of the typical haemolytic uraemic syndrome is mainly sufficient with dialysis and red blood cell transfusions. In the atypical form and in thrombotic thrombocytopenic purpura plasmapheresis might be indicated. The therapeutic effect of fresh frozen plasma is controversal. Prednisolon, heparin and antiplatelet agents have not proved to be effective. The new therapeutic methods, such as antioxidants and the recombinant von Willebrand factor multimer need further investigations.

Original languageHungarian
Pages (from-to)692-700
Number of pages9
JournalLege Artis Medicinae
Volume6
Issue number12
Publication statusPublished - 1996

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Hemolytic-Uremic Syndrome
Thrombotic Thrombocytopenic Purpura
Diarrhea
Shigella dysenteriae
Shiga Toxins
Erythrocyte Transfusion
Purpura
Escherichia coli O157
Plasmapheresis
Uremia
Platelet Aggregation Inhibitors
von Willebrand Factor
Therapeutic Uses
Prednisolone
Hemolysis
Acute Kidney Injury
Thrombocytopenia
Heparin
Dialysis
Antioxidants

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A haemolyticus uraemias szindroma uj vonatkozasai. / Túri, S.

In: Lege Artis Medicinae, Vol. 6, No. 12, 1996, p. 692-700.

Research output: Contribution to journalArticle

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