Ujabb adatok a hazai hantavírusok népegészségügyi jelentóségének vizsgálatához.

Translated title of the contribution: New data for the public health importance of hantaviruses in Hungary

E. Ferenczi, Gábor Rácz, Judit Szekeres, Katalin Balog, Etelka Tóth, M. Takács, Márta Csire, Ilona Mezey, G. Berencsi, Gábor Faludi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

INTRODUCTION: The authors present recent results in the Hungarian hantavirus ecology and epidemiology. Most of the research was done between 1992-2000. AIM: To determine the presence and geographic distribution of hantaviruses and to get more detailed information of human and small-mammal infection with these viruses in Hungary. METHODS: For diagnostic purposes (patients' sera), serosurvey of healthy persons and serological investigations of small mammals, the following tests were used: indirect fluorescent antibody, high density particle agglutination and enzyme-linked immunosorbent assay (ELISA). Virus isolation, antigen-, and nucleic acid detection were conducted for ecological investigations. RESULTS: 235 of 831 patients proved to be seropositive. 2257 sera of age matched Hungarian citizens above 20 years were tested in 2000. The average seropositivity proved to be about 10% using two different methods. Sera of 1512 individuals of nearly 20 different mammalian species were tested. Serological results revealed the prevalence of antibodies to human pathogen hantaviruses among rodents of about 7.25 percent. Molecular analysis of viral nucleic acid isolates from organs of four rodents proved directly the presence of viruses belonging to Puumala and Dobrava/Belgrade species in Hungary. Sequences corresponding to the Dobrava/Belgrade type viruses were found in two different rodent species. This suggests the existence of two hosts with different living preferences. CONCLUSIONS: At least two different human pathogen hantaviruses are circulating in Hungary. It has to be considered, that viruses belonging to the Dobrava/Belgrade species could emerge not only in the forested areas, but in the agricultural areas as well. Commercially available kits are not perfectly suitable for the detection of antibodies rised to domestic hantaviruses. It is necessary to built an appropriate laboratory for the hantavirus research in Hungary.

Original languageHungarian
Pages (from-to)467-474
Number of pages8
JournalOrvosi Hetilap
Volume144
Issue number10
Publication statusPublished - Mar 9 2003

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Hantavirus
Hungary
Public Health
Rodentia
Viruses
Nucleic Acids
Antibodies
Mammals
Serum
Agglutination
Virus Diseases
Ecology
Research
Epidemiology
Enzyme-Linked Immunosorbent Assay
Antigens

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ferenczi, E., Rácz, G., Szekeres, J., Balog, K., Tóth, E., Takács, M., ... Faludi, G. (2003). Ujabb adatok a hazai hantavírusok népegészségügyi jelentóségének vizsgálatához. Orvosi Hetilap, 144(10), 467-474.

Ujabb adatok a hazai hantavírusok népegészségügyi jelentóségének vizsgálatához. / Ferenczi, E.; Rácz, Gábor; Szekeres, Judit; Balog, Katalin; Tóth, Etelka; Takács, M.; Csire, Márta; Mezey, Ilona; Berencsi, G.; Faludi, Gábor.

In: Orvosi Hetilap, Vol. 144, No. 10, 09.03.2003, p. 467-474.

Research output: Contribution to journalArticle

Ferenczi, E, Rácz, G, Szekeres, J, Balog, K, Tóth, E, Takács, M, Csire, M, Mezey, I, Berencsi, G & Faludi, G 2003, 'Ujabb adatok a hazai hantavírusok népegészségügyi jelentóségének vizsgálatához.', Orvosi Hetilap, vol. 144, no. 10, pp. 467-474.
Ferenczi, E. ; Rácz, Gábor ; Szekeres, Judit ; Balog, Katalin ; Tóth, Etelka ; Takács, M. ; Csire, Márta ; Mezey, Ilona ; Berencsi, G. ; Faludi, Gábor. / Ujabb adatok a hazai hantavírusok népegészségügyi jelentóségének vizsgálatához. In: Orvosi Hetilap. 2003 ; Vol. 144, No. 10. pp. 467-474.
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AU - Balog, Katalin

AU - Tóth, Etelka

AU - Takács, M.

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AU - Faludi, Gábor

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