Anti-endomysium ellenanyag vizsgálattal felderített új coeliakia esetek gluten sensitiv betegek családjában és nem specifikus gastrointestinalis panaszok miatt vizsgált gyermekekben.

Translated title of the contribution: New cases of celiac disease detected by anti-endomysial antibody test in families of gluten-sensitive patients and among children examined for non-specific gastrointestinal complaints

I. Korponay-Szabó, J. Kovács, M. Lörincz, M. Körmendy, J. Sashegyi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Among 228 relatives of 101 gluten-sensitive patients, 13 anti-endomysium antibody (EmA) positive persons (7 children and 6 adults) were identified. In 12/13 cases jejunal biopsy confirmed severe villous atrophy consistent with celiac disease. In the single EmA positive sibling without villous atrophy the histology is thought to be influenced by a steroid treatment because of pulmonary disease. By routine EmA-testing 12 unexpected EmA positive patients were found out of 756 children with complaints and laboratory results otherwise not justifying jejunal biopsy at the first evaluation. Their initial diagnoses were: proteinuria, colitis, Crohn's disease, rickets, recurrent vomiting, resolved postinfectious lactase deficiency, "previously excluded" celiac disease. Severe villous atrophy could be demonstrated in all EmA positive patients subsequently. In further 204 EmA negative children the biopsy showed no atrophy. EmA positivity may reveal clinically not apparent severe villous atrophy emphasizing the role of a new non invasive and highly specific serological screening method for celiac disease.

Original languageHungarian
Pages (from-to)15-20
Number of pages6
JournalOrvosi Hetilap
Volume134
Issue number1
Publication statusPublished - Jan 3 1993

Fingerprint

Glutens
Celiac Disease
Anti-Idiotypic Antibodies
Atrophy
Antibodies
Biopsy
Lactase
Rickets
Colitis
Proteinuria
Crohn Disease
Lung Diseases
Vomiting
Siblings
Histology
Steroids

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Anti-endomysium ellenanyag vizsgálattal felderített új coeliakia esetek gluten sensitiv betegek családjában és nem specifikus gastrointestinalis panaszok miatt vizsgált gyermekekben. / Korponay-Szabó, I.; Kovács, J.; Lörincz, M.; Körmendy, M.; Sashegyi, J.

In: Orvosi Hetilap, Vol. 134, No. 1, 03.01.1993, p. 15-20.

Research output: Contribution to journalArticle

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