Prolactin (PRL) is a polypeptide hormone that is synthesised in and secreted from the mammotropes of the anterior pituitary gland. In mammals PRL not only subserves multiple roles during lactation but it also plays an essential role in the general homeostatis of the organism. The mediobasal hypothalamic dopaminergic system is the main physiological regulator of PRL secretion, however in the last few years several prolactin releasing and inhibiting factors have been postulated. Significant part of these factors is synthesised in the hypothalamic paraventricular and arcuate nuclei. Suckling stimulus of pups is the most effective physiological stimulus of PRL secretion. The information on the brain structures involved in this reflex is fairly limited. This review discusses the role of the hypothalamic dopaminergic and L-DOPAergic neurons in the control of PRL; the mechanism of action of the main PRL releasing and inhibiting factors in rats; and the possible role of R-salsolinol, recently isolated dopamine (DA) metabolite from the neuro-intermediate lobe of the pituitary gland, in the regulation of tonic the DA release. Our presented data and mechanisms are based on animal experiments.
|Number of pages||13|
|Publication status||Published - Nov 5 2007|
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