New aspects of the molecular constituents of tissue barriers

H. C. Bauer, A. Traweger, J. Zweimueller-Mayer, C. Lehner, H. Tempfer, I. Krizbai, I. Wilhelm, H. Bauer

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Epithelial and endothelial tissue barriers are based on tight intercellular contacts (Tight Junctions, TJs) between neighbouring cells. TJs are multimeric complexes, located at the most apical border of the lateral membrane. So far, a plethora of proteins locating at tight intercellular contacts have been discovered, the role of which has just partly been unraveled. Yet, there is convincing evidence that many TJ proteins exert a dual role: They act as structural components at the junctional site and they are involved in signalling pathways leading to alterations of gene expression and cell behaviour (migration, proliferation). This review will shortly summarize the classical functions of TJs and TJ-related proteins and will introduce a new category, termed the "non-classical" functions of junctional proteins. A particular focus will be directed towards the nuclear targeting of junctional proteins and the downstream effects elicited by their intranuclear activities.

Original languageEnglish
Pages (from-to)7-21
Number of pages15
JournalJournal of Neural Transmission
Volume118
Issue number1
DOIs
Publication statusPublished - Jan 2011

Fingerprint

Tight Junctions
Tight Junction Proteins
Protein Transport
Endothelium
Cell Movement
Proteins
Epithelium
Gene Expression
Membranes

Keywords

  • Endothelia
  • Epithelia
  • Tight junctions
  • Tissue-barriers

ASJC Scopus subject areas

  • Biological Psychiatry
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Bauer, H. C., Traweger, A., Zweimueller-Mayer, J., Lehner, C., Tempfer, H., Krizbai, I., ... Bauer, H. (2011). New aspects of the molecular constituents of tissue barriers. Journal of Neural Transmission, 118(1), 7-21. https://doi.org/10.1007/s00702-010-0484-6

New aspects of the molecular constituents of tissue barriers. / Bauer, H. C.; Traweger, A.; Zweimueller-Mayer, J.; Lehner, C.; Tempfer, H.; Krizbai, I.; Wilhelm, I.; Bauer, H.

In: Journal of Neural Transmission, Vol. 118, No. 1, 01.2011, p. 7-21.

Research output: Contribution to journalArticle

Bauer, HC, Traweger, A, Zweimueller-Mayer, J, Lehner, C, Tempfer, H, Krizbai, I, Wilhelm, I & Bauer, H 2011, 'New aspects of the molecular constituents of tissue barriers', Journal of Neural Transmission, vol. 118, no. 1, pp. 7-21. https://doi.org/10.1007/s00702-010-0484-6
Bauer HC, Traweger A, Zweimueller-Mayer J, Lehner C, Tempfer H, Krizbai I et al. New aspects of the molecular constituents of tissue barriers. Journal of Neural Transmission. 2011 Jan;118(1):7-21. https://doi.org/10.1007/s00702-010-0484-6
Bauer, H. C. ; Traweger, A. ; Zweimueller-Mayer, J. ; Lehner, C. ; Tempfer, H. ; Krizbai, I. ; Wilhelm, I. ; Bauer, H. / New aspects of the molecular constituents of tissue barriers. In: Journal of Neural Transmission. 2011 ; Vol. 118, No. 1. pp. 7-21.
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