NEUE ASPEKTE DER METHOTREXAT-BLUTSPIEGELBESTIMMUNGEN BEI LEUKAMISCHEN KINDERN

Translated title of the contribution: New aspects of the determination of MTX serum concentration in children suffering from ALL

D. Schuler, J. Borsi, R. Koós, T. Révész, G. Kardos, P. Somló

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Serum and CSF concentrations after medium dosage of methotrexate (MTX; 500 mg/m2 - 1000 mg/m2) have been determined by an enzymatic assay during 142 infusions in children with ALL. If the dose of MTX was 500 mg/m2 MTX concentrations in CSF were under 10-6 M/l in 40% of the treatments but only in 22%, when the dose was increased to 1000 mg/m2. The systemic clearance of MTX was found to be increased significantly by the 2nd MTX treatment in children who relapsed thereafter. Such a phenomenon was not observed in children who continued in remission. The relapse free survival of children, whose MTX-clearance remained constant by the 2nd MTX treatment was significantly longer. No serious MTX toxicity has been observed in our patients.

Original languageGerman
Pages (from-to)765-768
Number of pages4
JournalMonatsschrift fur Kinderheilkunde
Volume134
Issue number10
Publication statusPublished - 1986

Fingerprint

Serum
Enzyme Assays
Methotrexate
Therapeutics
Recurrence
Survival

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Schuler, D., Borsi, J., Koós, R., Révész, T., Kardos, G., & Somló, P. (1986). NEUE ASPEKTE DER METHOTREXAT-BLUTSPIEGELBESTIMMUNGEN BEI LEUKAMISCHEN KINDERN. Monatsschrift fur Kinderheilkunde, 134(10), 765-768.

NEUE ASPEKTE DER METHOTREXAT-BLUTSPIEGELBESTIMMUNGEN BEI LEUKAMISCHEN KINDERN. / Schuler, D.; Borsi, J.; Koós, R.; Révész, T.; Kardos, G.; Somló, P.

In: Monatsschrift fur Kinderheilkunde, Vol. 134, No. 10, 1986, p. 765-768.

Research output: Contribution to journalArticle

Schuler, D, Borsi, J, Koós, R, Révész, T, Kardos, G & Somló, P 1986, 'NEUE ASPEKTE DER METHOTREXAT-BLUTSPIEGELBESTIMMUNGEN BEI LEUKAMISCHEN KINDERN', Monatsschrift fur Kinderheilkunde, vol. 134, no. 10, pp. 765-768.
Schuler, D. ; Borsi, J. ; Koós, R. ; Révész, T. ; Kardos, G. ; Somló, P. / NEUE ASPEKTE DER METHOTREXAT-BLUTSPIEGELBESTIMMUNGEN BEI LEUKAMISCHEN KINDERN. In: Monatsschrift fur Kinderheilkunde. 1986 ; Vol. 134, No. 10. pp. 765-768.
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