New approach for the synthesis of 3H-pyrrolo[2,3-c]isoquinoline derivatives

Bharat Dixit, József Balog, Z. Riedl, L. Drahos, G. Hajós

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Synthesis of new 2,3-diaryl-3H-pyrrolo[2,3-c]isoquinoline derivatives has been elaborated starting from isoquinoline-3-amine. Buchwald-Hartwig arylation and subsequent iodination in position 4 afforded 3-arylamino-4- iodoisoquinolines. These compounds were subjected to Sonogashira cross-coupling reactions with some selected acetylenes, and the resulting coupled products underwent cyclization in the presence of tetrabutylammonium fluoride to give title derivatives.

Original languageEnglish
Pages (from-to)3560-3565
Number of pages6
JournalTetrahedron
Volume68
Issue number18
DOIs
Publication statusPublished - May 6 2012

Fingerprint

Derivatives
Alkynes
Halogenation
Cyclization
Cross Reactions
Amines
isoquinoline
tetrabutylammonium

Keywords

  • Buchwald-Hartwig cross-coupling
  • Cyclization
  • Fused pyrrole
  • Iodination
  • Sonogashira cross-coupling

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

New approach for the synthesis of 3H-pyrrolo[2,3-c]isoquinoline derivatives. / Dixit, Bharat; Balog, József; Riedl, Z.; Drahos, L.; Hajós, G.

In: Tetrahedron, Vol. 68, No. 18, 06.05.2012, p. 3560-3565.

Research output: Contribution to journalArticle

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