New antifungal peptides. Synthesis, bioassays and initial structure prediction by CD spectroscopy

Mónica S. Olivella, Ana M. Rodríguez, Susana A. Zacchino, C. Somlai, B. Penke, Victor Farkas, A. Perczel, Ricardo D. Enriz

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The synthesis, in vitro evaluation and conformational study of KKWKMRRNQFWIKIQR-NH2, HFRWRQIKIWFQNRRMKWKK-NH2 and RQPKIWFPNRRKPWKK-NH2 acting as antifungal agents are reported. These peptides displayed a moderate but significant antifungal effect against both pathogenic fungi Candida albicans and Cryptococcus neoformans. The conformational analysis of these peptides was carried out using both theoretical and experimental methods.

Original languageEnglish
Pages (from-to)4808-4811
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number16
DOIs
Publication statusPublished - Aug 15 2010

Fingerprint

Bioassay
Biological Assay
Spectrum Analysis
Spectroscopy
Peptides
Cryptococcus neoformans
Candida
Antifungal Agents
Fungi
Candida albicans
In Vitro Techniques

Keywords

  • Antifungal
  • Circular dichroism
  • Conformation
  • Peptides

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry
  • Medicine(all)

Cite this

New antifungal peptides. Synthesis, bioassays and initial structure prediction by CD spectroscopy. / Olivella, Mónica S.; Rodríguez, Ana M.; Zacchino, Susana A.; Somlai, C.; Penke, B.; Farkas, Victor; Perczel, A.; Enriz, Ricardo D.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 20, No. 16, 15.08.2010, p. 4808-4811.

Research output: Contribution to journalArticle

Olivella, Mónica S. ; Rodríguez, Ana M. ; Zacchino, Susana A. ; Somlai, C. ; Penke, B. ; Farkas, Victor ; Perczel, A. ; Enriz, Ricardo D. / New antifungal peptides. Synthesis, bioassays and initial structure prediction by CD spectroscopy. In: Bioorganic and Medicinal Chemistry Letters. 2010 ; Vol. 20, No. 16. pp. 4808-4811.
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