New antifungal peptides. Synthesis, bioassays and initial structure prediction by CD spectroscopy

Mónica S. Olivella, Ana M. Rodríguez, Susana A. Zacchino, Csaba Somlai, Botond Penke, Victor Farkas, András Perczel, Ricardo D. Enriz

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The synthesis, in vitro evaluation and conformational study of KKWKMRRNQFWIKIQR-NH2, HFRWRQIKIWFQNRRMKWKK-NH2 and RQPKIWFPNRRKPWKK-NH2 acting as antifungal agents are reported. These peptides displayed a moderate but significant antifungal effect against both pathogenic fungi Candida albicans and Cryptococcus neoformans. The conformational analysis of these peptides was carried out using both theoretical and experimental methods.

Original languageEnglish
Pages (from-to)4808-4811
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number16
DOIs
Publication statusPublished - Aug 15 2010

Keywords

  • Antifungal
  • Circular dichroism
  • Conformation
  • Peptides

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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