Új antikoagulánsok a vénás thromboembolia megelo″zésében és kezelésében

Translated title of the contribution: New anticoagulants in the prevention and treatment of venous thromboembolism

Mátyás Keltai, Katalin Keltai

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Clinical data on the risk factors, incidence, consequences and current treatment options of venous thromboembolism are reviewed. Current guidelines advise anticoagulant treatment for a few weeks or months in immobilized patients treated in hospital, and after major surgery. The initial treatment is based on heparin, followed by vitamin K antagonist treatment. Recently a number of new, partially orally administered medications have undergone clinical investigations and based on the results three of them were also registered for the prevention and treatment of venous thromboembolism. Direct thrombin inhibitors, direct and indirect Factor Xa inhibitors exhibited proven non-inferiority or superiority compared with traditional treatment options. The superior efficacy or non-inferiority was not accompanied with an increase in the bleeding risk. Results of the most important clinical trials are reviewed. Based on these results, prevention and treatment of venous thromboembolism will change substantially in the next future.

Translated title of the contributionNew anticoagulants in the prevention and treatment of venous thromboembolism
Original languageHungarian
Pages (from-to)983-992
Number of pages10
JournalOrvosi hetilap
Volume152
Issue number25
DOIs
Publication statusPublished - Jun 1 2011

ASJC Scopus subject areas

  • Medicine(all)

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