New access to enantiopure O,O'-dibenzoyltartaric acid

Resolution of the mixed calcium methoxyacetate by preferential crystallization

Ferenc Elekes, Zoltán Kovári, András Mravik, Zsolt Böcskei, E. Fogassy

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A convenient resolution of racemic O,O'-dibenzoyltartaric acid by preferential crystallization of its mixed calcium salt formed with methoxyacetic acid is described. The separation of the partially prepared salt 2 followed by a subsequent recrystallization results in a simple and effective resolution of the title compound during which pure enantiomers of 1 can be obtained even on a large scale. The crystal structure of the conglomerate forming complex 2 is also reported.

Original languageEnglish
Pages (from-to)2895-2900
Number of pages6
JournalTetrahedron Asymmetry
Volume9
Issue number16
DOIs
Publication statusPublished - Aug 21 1998

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Crystallization
calcium
Calcium
Salts
crystallization
salts
acids
Acids
Enantiomers
enantiomers
Crystal structure
crystal structure
2,3-bis(benzoyloxy)tartaric acid
methoxyacetic acid

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Organic Chemistry
  • Materials Chemistry
  • Drug Discovery

Cite this

New access to enantiopure O,O'-dibenzoyltartaric acid : Resolution of the mixed calcium methoxyacetate by preferential crystallization. / Elekes, Ferenc; Kovári, Zoltán; Mravik, András; Böcskei, Zsolt; Fogassy, E.

In: Tetrahedron Asymmetry, Vol. 9, No. 16, 21.08.1998, p. 2895-2900.

Research output: Contribution to journalArticle

Elekes, Ferenc ; Kovári, Zoltán ; Mravik, András ; Böcskei, Zsolt ; Fogassy, E. / New access to enantiopure O,O'-dibenzoyltartaric acid : Resolution of the mixed calcium methoxyacetate by preferential crystallization. In: Tetrahedron Asymmetry. 1998 ; Vol. 9, No. 16. pp. 2895-2900.
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