New 2-methoxy acetylenic acids and pyrazole alkaloids from the marine sponge Cinachyrella sp.

Amin Mokhlesi, Rudolf Hartmann, T. Kurtán, Horst Weber, Wenhan Lin, Chaidir Chaidir, Werner E.G. M ller, Georgios Daletos, Peter Proksch

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6 Citations (Scopus)

Abstract

Three new 2-methoxy acetylenic acids (1–3) and a known derivative (4), in addition to three new natural pyrazole alkaloids (5–7) were isolated from an Indonesian marine sponge of the genus Cinachyrella. Compounds 5 and 6 have previously been reported as synthetic compounds. The structures of the new compounds were established on the basis of one- and two-dimensional NMR spectroscopy as well as by mass spectrometric data. The absolute configuration of the new acetylenic acid derivatives (1–3) was established by ECD spectroscopy. All isolated compounds were evaluated for their cytotoxicity against L5178Y mouse lymphoma cells. Compounds 1–4 exhibited strong activity with an IC50 value of 0.3 µM. A plausible biosynthetic pathway for the pyrazole metabolites 5–7 is proposed.

Original languageEnglish
Article number356
JournalMarine Drugs
Volume15
Issue number11
DOIs
Publication statusPublished - Nov 1 2017

Keywords

  • 2-methoxy acetylenic acid
  • Cinachyrella sp.
  • Marine sponge
  • Natural products
  • Pyrazole alkaloid

ASJC Scopus subject areas

  • Drug Discovery

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  • Cite this

    Mokhlesi, A., Hartmann, R., Kurtán, T., Weber, H., Lin, W., Chaidir, C., M ller, W. E. G., Daletos, G., & Proksch, P. (2017). New 2-methoxy acetylenic acids and pyrazole alkaloids from the marine sponge Cinachyrella sp. Marine Drugs, 15(11), [356]. https://doi.org/10.3390/md15110356