Neutralizing antibodies and serum interferon levels in the different stages of HIV infection

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Abstract

The sera of patients infected with HIV were investigated for neutralizing antibodies (NA) and interferons. All samples from asymptomatic HIV carriers contained NA in high titres. In the sera of patients with AIDS related complex and AIDS the antibodies were found rarely and in lower titres. An early peak of acid-labile interferon (IFN)-α was observed in asymptomatic HIV-infected persons, and a late peak was found in AIDS patients. The data suggest that HIV NA may have beneficial effect in the asymptomatic phase. The presence of acid-labile IFN-α may indicate stimulation of IFN system by HIV-infected cells.

Original languageEnglish
Pages (from-to)164-170
Number of pages7
JournalActa virologica
Volume34
Issue number2
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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