Neurovascular Inflammaging in Health and Disease

Ádám Mészáros, Kinga Molnár, Bernát Nógrádi, Zsófia Hernádi, Ádám Nyúl-Tóth, Imola Wilhelm, István A. Krizbai

Research output: Contribution to journalReview article

Abstract

Aging is characterized by a chronic low-grade sterile inflammation dubbed as inflammaging, which in part originates from accumulating cellular debris. These, acting as danger signals with many intrinsic factors such as cytokines, are sensed by a network of pattern recognition receptors and other cognate receptors, leading to the activation of inflammasomes. Due to the inflammasome activity-dependent increase in the levels of pro-inflammatory interleukins (IL-1β, IL-18), inflammation is initiated, resulting in tissue injury in various organs, the brain and the spinal cord included. Similarly, in age-related diseases of the central nervous system (CNS), inflammasome activation is a prominent moment, in which cells of the neurovascular unit occupy a significant position. In this review, we discuss the inflammatory changes in normal aging and summarize the current knowledge on the role of inflammasomes and contributing mechanisms in common CNS diseases, namely Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and stroke, all of which occur more frequently with aging.

Original languageEnglish
JournalCells
Volume9
Issue number7
DOIs
Publication statusPublished - Jul 4 2020

Keywords

  • aging
  • inflammaging
  • inflammasome
  • neurodegeneration
  • neuroinflammation
  • neurovascular unit
  • stroke

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  • Cite this

    Mészáros, Á., Molnár, K., Nógrádi, B., Hernádi, Z., Nyúl-Tóth, Á., Wilhelm, I., & Krizbai, I. A. (2020). Neurovascular Inflammaging in Health and Disease. Cells, 9(7). https://doi.org/10.3390/cells9071614