Neurotrophin-mediated neuroprotection by solid fetal telencephalic graft in middle cerebral artery occlusion: A preventive approach

T. Hortobágyi, T. Harkany, R. Reisch, R. Urbanics, M. Kálmán, C. Nyakas, Z. Nagy

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

In the present study, embryonic rat neocortex was implanted into the parietal subcortical area of adult naive animals. On the 7th day, the middle cerebral artery was permanently occluded ipsilateral to the graft. Twenty- four hours after middle cerebral artery occlusion, the extent of infarct was visualized by means of 2,3,5-triphenyltetrazolium chloride histochemistry and quantified in four different standardized coronal plains. Subsequently, the effects of fetal tissue grafting and those of transplantation were identified by using glial fibrillary acidic protein and nerve growth factor immunocytochemistry. The grafts integrated well into their new environment and significantly reduced the size of infarct in middle cerebral arteryoccluded animals compared with both sham-operated and control rats 24 h postoperation. The underlying mechanism of this phenomenon might be an increased neurotrophic, particularly nerve growth factor, release by the grafted fetal tissue. Moreover, reactive astroglial cells may also trigger the neuroprotection by additional ischemia-induced nerve growth factor release. The present data demonstrate the potential neurotrophin-mediated protective effects of fetal brain tissue implanted into the adult rat brain before unilateral middle cerebral artery occlusion and the beneficial effects of astrocyte activation.

Original languageEnglish
Pages (from-to)185-191
Number of pages7
JournalBrain Research Bulletin
Volume47
Issue number2
DOIs
Publication statusPublished - Sep 15 1998

Keywords

  • Fetal tissue transplantation
  • Middle cerebral artery occlusion
  • Neuroprotection
  • Neurotrophic factors
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

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