Neurotransmitters and neuropeptides in the baroreceptor reflex arc: Connections between the nucleus of the solitary tract and the ventrolateral medulla oblongata in the rat

M. Palkóvits, E. Mezey, M. Fodor, D. Ganten, U. Bahner, H. Geiger, A. Heidland

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The primary baroreceptor area (nucleus of the solitary tract - NTS) is anatomically interconnected with the rostral ("vasomotor area" and the caudal ("vasodepressor area" ventrolateral medulla by a well-defined arc of neuronal pathways. The chemical character and the direction of these pathways have been investigated with immunohistochemical and neurochemical techniques in intact and brainstem-operated rats. The transection of the neuronal arc resulted in an accumulation of tyrosine hydroxylase immunoreactivity in a small group of cells in the NTS adjacent to the area postrema, ipsilateral to the knife cut. Decreased angiotensinogen mRNA and atrial natriuretic peptide concentrations were measured in the ventrolateral medulla after the cut, and an accumulation of angiotensin II-immunoreactivity was found in neuronal perikarya in the ipsilateral NTS. Intracranial vagotomy caused marked depletions in glutamate levels in the subcommissural portion of the NTS and in the caudal ventrolateral medulla but nowhere else in the brainstem investigated including the rostral ventrolateral medulla.

Original languageEnglish
Pages (from-to)101-113
Number of pages13
JournalClinical and Experimental Hypertension
Volume17
Issue number1-2
DOIs
Publication statusPublished - 1995

Fingerprint

Medulla Oblongata
Solitary Nucleus
Baroreflex
Neuropeptides
Brain Stem
Neurotransmitter Agents
Area Postrema
Angiotensinogen
Pressoreceptors
Vagotomy
Tyrosine 3-Monooxygenase
Atrial Natriuretic Factor
Angiotensin II
Glutamic Acid
Messenger RNA
Direction compound

Keywords

  • Angiotensinogen mRNA
  • Atrial Natriuretic Polypeptide
  • Glutamate
  • Nucleus of the Solitary Tract
  • Tyrosine Hydroxylase
  • Ventrolateral Medulla Oblongata

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology

Cite this

Neurotransmitters and neuropeptides in the baroreceptor reflex arc : Connections between the nucleus of the solitary tract and the ventrolateral medulla oblongata in the rat. / Palkóvits, M.; Mezey, E.; Fodor, M.; Ganten, D.; Bahner, U.; Geiger, H.; Heidland, A.

In: Clinical and Experimental Hypertension, Vol. 17, No. 1-2, 1995, p. 101-113.

Research output: Contribution to journalArticle

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