Neurotransmission of the antidepressant-like effects of the growth hormone-releasing hormone antagonist MZ-4-71

M. Tanaka, A. V. Schally, G. Telegdy

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

MZ-4-71 is an antagonist of growth hormone-releasing hormone (GH-RH) which suppresses the secretion of GH-RH. It has been shown that MZ-4-71 has antidepressive-like effects in a modified forced swimming test (FST) in mice, exerts anxiolytic effects in an elevated plus maze test, improves memory consolidation in passive avoidance learning, and corrects the impairment of memory consolidation caused by β-amyloid 25-35in mice. However, little is known about the mechanisms of action of MZ-4-71 on brain functions. The involvement of the adrenergic, serotonergic, cholinergic, dopaminergic or GABA-ergic receptors in the antidepressant-like action of MZ-4-71 (1.0 μg/2 μl, intracerebroventricular (i.c.v.)) was studied in a modified mouse forced swimming test (FST). Mice were pretreated with a non-selective α-adrenergic receptor antagonist, phenoxybenzamine, an α1/α2β-adrenergic receptor antagonist prazosin, an α2-adrenergic receptor antagonist, yohimbine, a β-adrenergic receptor antagonist, propranolol, a mixed 5-HT1/5-HT2 serotonergic receptor antagonist methysergide, a non-selective 5-HT2 serotonergic receptor antagonist, cyproheptadine, a non-selective muscarinic acetylcholine receptor antagonist, atropine, a D2, D3, D4 dopamine receptor antagonist, haloperidol or a γ-aminobutyric acid subunit A (GABA-A) receptor antagonist bicuculline.Phenoxybenzamine, prazosin, methysergide, cyproheptadine and atropine prevented the effects of MZ-4-71 on the immobility, the climbing and the swimming times. Yohimbine, propranolol, haloperidol and bicuculline did not change the effects of MZ-4-71.The results demonstrated that the antidepressant-like effects of MZ-4-71 in this modified mouse FST are mediated, at least in part, by the an interaction of the α1-adrenergic, 5-HT1/5-HT2 serotonergic, and muscarinic acetylcholine receptors.

Original languageEnglish
Pages (from-to)388-391
Number of pages4
JournalBehavioural Brain Research
Volume228
Issue number2
DOIs
Publication statusPublished - Mar 17 2012

Fingerprint

Hormone Antagonists
Growth Hormone-Releasing Hormone
Synaptic Transmission
Antidepressive Agents
Adrenergic Antagonists
Cyproheptadine
Methysergide
Phenoxybenzamine
Bicuculline
Yohimbine
Prazosin
Muscarinic Receptors
Haloperidol
Atropine
Propranolol
Adrenergic Agents
Avoidance Learning
Aminobutyrates
GABA-A Receptor Antagonists
GABA Receptors

Keywords

  • Depression
  • GH-RH antagonist
  • MZ-4-71
  • Receptor interactions

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Neurotransmission of the antidepressant-like effects of the growth hormone-releasing hormone antagonist MZ-4-71. / Tanaka, M.; Schally, A. V.; Telegdy, G.

In: Behavioural Brain Research, Vol. 228, No. 2, 17.03.2012, p. 388-391.

Research output: Contribution to journalArticle

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