Neurotoxin induced nerve cell degeneration: Possible involvement of calcium

G. Jancsó, Sarolta Karcsú, Elizabeth Király, Attila Szebeni, Lajos Tóth, Ernó Bácsy, Ferenc Joó, A. Párducz

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

Neurotoxin induced nerve cell degeneration has been studied in sensory ganglia of newborn and in the area postrema of adult rats following the administration of the selective sensory neurotoxin, capsaicin and the amino acid excitotoxin, glutamic acid, respectively. Light microscopic histochemical, autoradiographic, electroncytochemical and X-ray microanalytical studies revealed that degeneration of certain small-sized, type B primary sensory neurons, induced by capsaicin, was associated with a marked accumulation of calcium predominantly in mitochondria of the damaged ganglion cells. Similarly, monosodium glutamate treatment resulted in the appearance of calcium-containing electron-dense granules in mitochondria of degenerating area postrema neurons. In addition, after a combined administration of 45Ca2+ and capsaicin or monosodium glutamate, significantly higher levels of radioactivity have been detected by liquid scintillation spectroscopy in the Gasserian ganglia and the area postrema, respectively. It is concluded that an enhancement in intracellular calcium level may be intimately involved in the process of neuronal cell death and may represent a common basic mechanism responsible for the development of cellular events leading ultimately to the degeneration of nerve cells.

Original languageEnglish
Pages (from-to)211-216
Number of pages6
JournalBrain Research
Volume295
Issue number2
DOIs
Publication statusPublished - Mar 19 1984

Fingerprint

Area Postrema
Nerve Degeneration
Capsaicin
Neurotoxins
Sodium Glutamate
Calcium
Neurons
Mitochondria
Sensory Ganglia
Trigeminal Ganglion
Sensory Receptor Cells
Ganglia
Radioactivity
Glutamic Acid
Spectrum Analysis
Cell Death
X-Rays
Electrons
Light
Amino Acids

Keywords

  • area postrema
  • calcium
  • capsaicin
  • monosodium-l-glutamate
  • nerve cell death
  • neurotoxins
  • primary sensory neurons

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Neurotoxin induced nerve cell degeneration : Possible involvement of calcium. / Jancsó, G.; Karcsú, Sarolta; Király, Elizabeth; Szebeni, Attila; Tóth, Lajos; Bácsy, Ernó; Joó, Ferenc; Párducz, A.

In: Brain Research, Vol. 295, No. 2, 19.03.1984, p. 211-216.

Research output: Contribution to journalArticle

Jancsó, G, Karcsú, S, Király, E, Szebeni, A, Tóth, L, Bácsy, E, Joó, F & Párducz, A 1984, 'Neurotoxin induced nerve cell degeneration: Possible involvement of calcium', Brain Research, vol. 295, no. 2, pp. 211-216. https://doi.org/10.1016/0006-8993(84)90969-7
Jancsó, G. ; Karcsú, Sarolta ; Király, Elizabeth ; Szebeni, Attila ; Tóth, Lajos ; Bácsy, Ernó ; Joó, Ferenc ; Párducz, A. / Neurotoxin induced nerve cell degeneration : Possible involvement of calcium. In: Brain Research. 1984 ; Vol. 295, No. 2. pp. 211-216.
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