Neirotoksichnost' zagriaznitelei okruzhaiushchei sredy: éffekty olova (Sn2+) na indutsirovannye atsetilkholinom toki v neronakh bol'shogo prudovika.

Translated title of the contribution: Neurotoxicity of the environmental pollutants: tin (Sn2+) effects on currents induced by acetylcholine in the snail neurons

J. Salanki, J. Gyeri, A. Platokhin, K. S. Rozsa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In isolated single neurone or in whole ganglia preparation, SnCl2 caused a decrease in the acetylcholine-induced inward current in a dose-dependent way. Threshold concentration was 0.1 mkM and saturated at 5 mkM SnCl2. After 10-min. pre-treatment with SnCl2 the effect was more obvious (by 20%) than after 3-min pre-treatment. Sn(CH3)2 decreased the amplitude of Ach-induced current similarly to the inorganic Sn. The effect of Sn(CH3)2 was irreversible. The findings support earlier data that the agonist-activated channels are important targets for toxic metals. Direct action upon neuronal membrane seems to be an important event in modulation of synaptic transmission.

Original languageRussian
Pages (from-to)1061-1073
Number of pages13
JournalRossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova / Rossiiskaia akademiia nauk
Volume84
Issue number10
Publication statusPublished - Oct 1998

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ASJC Scopus subject areas

  • Medicine(all)

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