Neuropsychiatric symptoms in untreated parkinson’s disease

Szabolcs Szatmari, Ben Min Woo Illigens, Timo Siepmann, Alexandra Pinter, Annamaria Takats, D. Bereczki

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Neuropsychiatric and cognitive symptoms are common in Parkinson’s disease (PD) and may precede and exceed motor symptoms as major factors impacting disease course and quality of life. Neuropsychiatric symptoms (NPS) in PD are various and are attributed to pathologic changes within multiple brain regions, to psychological stress, and to adverse effects of dopamine replacement therapy. Sleep disorders and mood symptoms such as apathy, depression, and anxiety may antedate the development of motor symptoms by years, while other NPS such as impulse control disorders, psychosis, and cognitive impairment are more common in later stages of the disease. Few studies report on NPS in the early, untreated phase of PD. We reviewed the current literature on NPS in PD with a focus on the early, drug-naive stages of PD. Among these early disease stages, premotor and early motor phases were separately addressed in our review, highlighting the underlying pathophysiological mechanisms as well as epidemiological characteristics, clinical features, risk factors, and available techniques of clinical assessment.

Original languageEnglish
Pages (from-to)815-826
Number of pages12
JournalNeuropsychiatric Disease and Treatment
Volume13
DOIs
Publication statusPublished - Mar 16 2017

Fingerprint

Parkinson Disease
Disruptive, Impulse Control, and Conduct Disorders
Apathy
Neurobehavioral Manifestations
Psychological Stress
Psychotic Disorders
Dopamine
Anxiety
Quality of Life
Depression
Brain
Pharmaceutical Preparations
Therapeutics

Keywords

  • Neuropsychiatric symptoms
  • Parkinson’s disease
  • Untreated

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Neuropsychiatric symptoms in untreated parkinson’s disease. / Szatmari, Szabolcs; Illigens, Ben Min Woo; Siepmann, Timo; Pinter, Alexandra; Takats, Annamaria; Bereczki, D.

In: Neuropsychiatric Disease and Treatment, Vol. 13, 16.03.2017, p. 815-826.

Research output: Contribution to journalReview article

Szatmari, Szabolcs ; Illigens, Ben Min Woo ; Siepmann, Timo ; Pinter, Alexandra ; Takats, Annamaria ; Bereczki, D. / Neuropsychiatric symptoms in untreated parkinson’s disease. In: Neuropsychiatric Disease and Treatment. 2017 ; Vol. 13. pp. 815-826.
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