Neuroprotective effects of PACAP38 in a rat model of transient focal ischemia under various experimental conditions

D. Reglodi, Aniko Somogyvari-Vigh, Sandor Vigh, Jerome L. Maderdrut, Akira Arimura

Research output: Contribution to journalArticle

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Abstract

In the study reported here, we investigated the neuroprotective effect of PACAP38 in a rat model of middle cerebral artery occlusion (MCAO) under various experimental conditions. Stroke patients often develop mild hyperthermia that increases the infarct size and worsens the outcome. We compared the neuroprotective effect of PACAP38 in normothermic and moderately hyperthermic animals. Brain damage was more extensive in the hyperthermic animals, but PACAP38 significantly reduced the infarct size, measured 48 h after MCAO, in both the normothermic and the moderately hyperthermic animals, by more than 50%. However, a significant neuroprotection with PACAP38 could only be demonstrated when animals with no definite circling behavior and/or convulsions were excluded from the evaluations. In conclusion, moderate hyperthermia did not influence the effect of PACAP38, but animals with questionable brain damage or convulsions must be excluded from the sample in order to demonstrate the neuroprotection with PACAP38.

Original languageEnglish
Pages (from-to)119-128
Number of pages10
JournalAnnals of the New York Academy of Sciences
Volume921
Publication statusPublished - 2000

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Pituitary Adenylate Cyclase-Activating Polypeptide
Neuroprotective Agents
Rats
Ischemia
Animals
Middle Cerebral Artery Infarction
Brain
Seizures
Fever
Rat
Stroke

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Neuroprotective effects of PACAP38 in a rat model of transient focal ischemia under various experimental conditions. / Reglodi, D.; Somogyvari-Vigh, Aniko; Vigh, Sandor; Maderdrut, Jerome L.; Arimura, Akira.

In: Annals of the New York Academy of Sciences, Vol. 921, 2000, p. 119-128.

Research output: Contribution to journalArticle

Reglodi, D. ; Somogyvari-Vigh, Aniko ; Vigh, Sandor ; Maderdrut, Jerome L. ; Arimura, Akira. / Neuroprotective effects of PACAP38 in a rat model of transient focal ischemia under various experimental conditions. In: Annals of the New York Academy of Sciences. 2000 ; Vol. 921. pp. 119-128.
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