Neuroprotective effects of a specific multi-nutrient intervention against Aβ 42-induced toxicity in rats

Martijn C. De Wilde, B. Penke, Eline M. Van Der Beek, Almar A M Kuipers, Patrick J. Kamphuis, Laus M. Broersen

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia in the elderly. Substantial evidence suggests a role for nutrition in the management of AD and especially suggests that interventions with combinations of nutrients are more effective than single-nutrient interventions. The specific multi-nutrient combination Fortasyn™Connect (FC), shown to improve memory in AD, provides phosphatide precursors and cofactors and is designed to stimulate the formation of phospholipids, neuronal membranes, and synapses. The composition comprises nucleotides, omega-3 polyunsaturated fatty acids (n3 PUFA), choline, B-vitamins, phospholipids, and antioxidants. The current study explored the protective properties of FC in a membrane toxicity model of AD, the amyloid-β 1-42 (Aβ 42) infused rat, which shows reduced exploratory behavior in an Open Field and impaired cholinergic functioning. To this end, rats were fed an FC enriched diet or a control diet and five weeks later infused with vehicle or Aβ 42 into the lateral ventricle. Ten weeks post-infusion Aβ 42-rats fed the FC diet showed increased membrane n3 PUFA and phosphatidylcholine content while they did not show the reductions in exploratory behavior or in choline acetyltransferase (ChAT) and vesicular acetylcholine transporter (VAChT) immunoreactivity that were seen in Aβ 42-rats fed the control diet. We conclude that FC protects the cholinergic system against Aβ 42-induced toxicity and speculate that the effects of FC on membrane formation and composition might be supportive for this protective effect. Based on these data a long-term intervention study was started in the prodromal stages of AD (NTR1705, LipiDiDiet, EU FP7).

Original languageEnglish
Pages (from-to)327-339
Number of pages13
JournalJournal of Alzheimer's Disease
Volume27
Issue number2
DOIs
Publication statusPublished - 2011

Fingerprint

Neuroprotective Agents
Alzheimer Disease
Diet
Food
Phospholipids
Exploratory Behavior
Membranes
Omega-3 Fatty Acids
Unsaturated Fatty Acids
Cholinergic Agents
Nucleotides
Vesicular Acetylcholine Transport Proteins
Prodromal Symptoms
Vitamin B Complex
Choline O-Acetyltransferase
Lateral Ventricles
Choline
Phosphatidylcholines
Amyloid
Neurodegenerative Diseases

Keywords

  • Alzheimer's disease
  • amyloid-β
  • cholinergic markers
  • dietary intervention
  • dietary precursors
  • membrane
  • nutrition
  • protection

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

Neuroprotective effects of a specific multi-nutrient intervention against Aβ 42-induced toxicity in rats. / De Wilde, Martijn C.; Penke, B.; Van Der Beek, Eline M.; Kuipers, Almar A M; Kamphuis, Patrick J.; Broersen, Laus M.

In: Journal of Alzheimer's Disease, Vol. 27, No. 2, 2011, p. 327-339.

Research output: Contribution to journalArticle

De Wilde, Martijn C. ; Penke, B. ; Van Der Beek, Eline M. ; Kuipers, Almar A M ; Kamphuis, Patrick J. ; Broersen, Laus M. / Neuroprotective effects of a specific multi-nutrient intervention against Aβ 42-induced toxicity in rats. In: Journal of Alzheimer's Disease. 2011 ; Vol. 27, No. 2. pp. 327-339.
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