Neuroprotection achieved in the ischaemic rat cortex with l-kynurenine sulphate

H. Robotka, K. Sas, Márta Ágoston, Éva Rózsa, G. Szénási, Gábor Gigler, L. Vécsei, J. Toldi

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

l-Kynurenine is a metabolic precursor of kynurenic acid, which is one of the few known endogenous N-methyl-d-aspartate receptor inhibitors. In contrast with kynurenic acid, l-kynurenine is transported across the blood-brain barrier, and it may therefore come into consideration as a therapeutic agent in certain neurobiological disorders, e.g. ischaemia-induced events. The present study evaluated the effect of l-kynurenine administration (300 mg/kg i.p.) on the global ischaemic brain cortex both pre- and post-ischemic intervention. The statistical evaluation revealed that l-kynurenine administration beneficially decreased the number of neurones injured per mm2 in the cortex, not only in the pre-treated animals, but also in those which received l-kynurenine after the ischaemic insult. It is concluded that even the post-traumatic administration of l-kynurenine may be of substantial therapeutic benefit in the treatment of global brain ischaemia. This is the first histological proof of the neuroprotective effect achieved by the post-traumatic administration of l-kynurenine in the global ischaemic cortex.

Original languageEnglish
Pages (from-to)915-919
Number of pages5
JournalLife Sciences
Volume82
Issue number17-18
DOIs
Publication statusPublished - Apr 23 2008

Fingerprint

Kynurenine
Sulfates
Rats
Kynurenic Acid
Brain
Neuroprotective Agents
Neuroprotection
Brain Ischemia
Blood-Brain Barrier
Neurons
Animals
Ischemia
Therapeutics

Keywords

  • Fluoro-Jade B
  • Global ischaemia
  • Kynurenic acid
  • Kynurenine
  • Neuroprotection

ASJC Scopus subject areas

  • Pharmacology

Cite this

Neuroprotection achieved in the ischaemic rat cortex with l-kynurenine sulphate. / Robotka, H.; Sas, K.; Ágoston, Márta; Rózsa, Éva; Szénási, G.; Gigler, Gábor; Vécsei, L.; Toldi, J.

In: Life Sciences, Vol. 82, No. 17-18, 23.04.2008, p. 915-919.

Research output: Contribution to journalArticle

@article{96a03dfc29eb4cb3a0d573cee506788a,
title = "Neuroprotection achieved in the ischaemic rat cortex with l-kynurenine sulphate",
abstract = "l-Kynurenine is a metabolic precursor of kynurenic acid, which is one of the few known endogenous N-methyl-d-aspartate receptor inhibitors. In contrast with kynurenic acid, l-kynurenine is transported across the blood-brain barrier, and it may therefore come into consideration as a therapeutic agent in certain neurobiological disorders, e.g. ischaemia-induced events. The present study evaluated the effect of l-kynurenine administration (300 mg/kg i.p.) on the global ischaemic brain cortex both pre- and post-ischemic intervention. The statistical evaluation revealed that l-kynurenine administration beneficially decreased the number of neurones injured per mm2 in the cortex, not only in the pre-treated animals, but also in those which received l-kynurenine after the ischaemic insult. It is concluded that even the post-traumatic administration of l-kynurenine may be of substantial therapeutic benefit in the treatment of global brain ischaemia. This is the first histological proof of the neuroprotective effect achieved by the post-traumatic administration of l-kynurenine in the global ischaemic cortex.",
keywords = "Fluoro-Jade B, Global ischaemia, Kynurenic acid, Kynurenine, Neuroprotection",
author = "H. Robotka and K. Sas and M{\'a}rta {\'A}goston and {\'E}va R{\'o}zsa and G. Sz{\'e}n{\'a}si and G{\'a}bor Gigler and L. V{\'e}csei and J. Toldi",
year = "2008",
month = "4",
day = "23",
doi = "10.1016/j.lfs.2008.02.014",
language = "English",
volume = "82",
pages = "915--919",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "17-18",

}

TY - JOUR

T1 - Neuroprotection achieved in the ischaemic rat cortex with l-kynurenine sulphate

AU - Robotka, H.

AU - Sas, K.

AU - Ágoston, Márta

AU - Rózsa, Éva

AU - Szénási, G.

AU - Gigler, Gábor

AU - Vécsei, L.

AU - Toldi, J.

PY - 2008/4/23

Y1 - 2008/4/23

N2 - l-Kynurenine is a metabolic precursor of kynurenic acid, which is one of the few known endogenous N-methyl-d-aspartate receptor inhibitors. In contrast with kynurenic acid, l-kynurenine is transported across the blood-brain barrier, and it may therefore come into consideration as a therapeutic agent in certain neurobiological disorders, e.g. ischaemia-induced events. The present study evaluated the effect of l-kynurenine administration (300 mg/kg i.p.) on the global ischaemic brain cortex both pre- and post-ischemic intervention. The statistical evaluation revealed that l-kynurenine administration beneficially decreased the number of neurones injured per mm2 in the cortex, not only in the pre-treated animals, but also in those which received l-kynurenine after the ischaemic insult. It is concluded that even the post-traumatic administration of l-kynurenine may be of substantial therapeutic benefit in the treatment of global brain ischaemia. This is the first histological proof of the neuroprotective effect achieved by the post-traumatic administration of l-kynurenine in the global ischaemic cortex.

AB - l-Kynurenine is a metabolic precursor of kynurenic acid, which is one of the few known endogenous N-methyl-d-aspartate receptor inhibitors. In contrast with kynurenic acid, l-kynurenine is transported across the blood-brain barrier, and it may therefore come into consideration as a therapeutic agent in certain neurobiological disorders, e.g. ischaemia-induced events. The present study evaluated the effect of l-kynurenine administration (300 mg/kg i.p.) on the global ischaemic brain cortex both pre- and post-ischemic intervention. The statistical evaluation revealed that l-kynurenine administration beneficially decreased the number of neurones injured per mm2 in the cortex, not only in the pre-treated animals, but also in those which received l-kynurenine after the ischaemic insult. It is concluded that even the post-traumatic administration of l-kynurenine may be of substantial therapeutic benefit in the treatment of global brain ischaemia. This is the first histological proof of the neuroprotective effect achieved by the post-traumatic administration of l-kynurenine in the global ischaemic cortex.

KW - Fluoro-Jade B

KW - Global ischaemia

KW - Kynurenic acid

KW - Kynurenine

KW - Neuroprotection

UR - http://www.scopus.com/inward/record.url?scp=41749106197&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=41749106197&partnerID=8YFLogxK

U2 - 10.1016/j.lfs.2008.02.014

DO - 10.1016/j.lfs.2008.02.014

M3 - Article

C2 - 18387638

AN - SCOPUS:41749106197

VL - 82

SP - 915

EP - 919

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 17-18

ER -