Neurophysiological markers as early signs of organophosphate neurotoxicity

L. Nagymajtényi, I. Dési, Rózsa Lorencz

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The central and peripheral nervous system effects of acute and subchronic exposure to three organic phosphoro-acid esters (dimethoate, dichlorvos, parathion-methyl) were studied. CNS-dependent variables included mean EEG amplitude, mean frequency of the EEG, and the activity (power density) of six component frequency bands. Peripheral nervous system evaluations included determinations of conduction velocity, and both relative and absolute refractory periods. Cholinesterase activity was measured in blood, brain and other organs. The results indicate that acute large doses of these agents produce substantial changes in these measures of CNS and PNS function. In subchronic experiments it was found that a six weeks administration of 1 50 LD50 of the chemicals induced early functional changes in both the central and the peripheral nervous systems. It is recommended that when cholinesterase inhibition is detected in humans, functional evaluations of CNS and PNS should follow.

Original languageEnglish
Pages (from-to)429-434
Number of pages6
JournalNeurotoxicology and Teratology
Volume10
Issue number5
DOIs
Publication statusPublished - 1988

Fingerprint

Organophosphates
Cholinesterases
Peripheral Nervous System
Neurology
Electroencephalography
Peripheral Nervous System Agents
Central Nervous System
Dimethoate
Methyl Parathion
Dichlorvos
Organic acids
Lethal Dose 50
Refractory materials
Frequency bands
Brain
Esters
Blood
Acids
Experiments

Keywords

  • CNS Peripheral nervous system
  • Conduction velocity
  • Dichlorvos Parathion-methyl
  • Dimethoate
  • EEG EEG-bands
  • Neurophysiological markers
  • Organophosphates
  • Refractory period

ASJC Scopus subject areas

  • Neuroscience(all)
  • Cellular and Molecular Neuroscience
  • Toxicology

Cite this

Neurophysiological markers as early signs of organophosphate neurotoxicity. / Nagymajtényi, L.; Dési, I.; Lorencz, Rózsa.

In: Neurotoxicology and Teratology, Vol. 10, No. 5, 1988, p. 429-434.

Research output: Contribution to journalArticle

@article{16706ee0c9cc438e9c39548cc3c8bb5b,
title = "Neurophysiological markers as early signs of organophosphate neurotoxicity",
abstract = "The central and peripheral nervous system effects of acute and subchronic exposure to three organic phosphoro-acid esters (dimethoate, dichlorvos, parathion-methyl) were studied. CNS-dependent variables included mean EEG amplitude, mean frequency of the EEG, and the activity (power density) of six component frequency bands. Peripheral nervous system evaluations included determinations of conduction velocity, and both relative and absolute refractory periods. Cholinesterase activity was measured in blood, brain and other organs. The results indicate that acute large doses of these agents produce substantial changes in these measures of CNS and PNS function. In subchronic experiments it was found that a six weeks administration of 1 50 LD50 of the chemicals induced early functional changes in both the central and the peripheral nervous systems. It is recommended that when cholinesterase inhibition is detected in humans, functional evaluations of CNS and PNS should follow.",
keywords = "CNS Peripheral nervous system, Conduction velocity, Dichlorvos Parathion-methyl, Dimethoate, EEG EEG-bands, Neurophysiological markers, Organophosphates, Refractory period",
author = "L. Nagymajt{\'e}nyi and I. D{\'e}si and R{\'o}zsa Lorencz",
year = "1988",
doi = "10.1016/0892-0362(88)90004-9",
language = "English",
volume = "10",
pages = "429--434",
journal = "Neurotoxicology and Teratology",
issn = "0892-0362",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Neurophysiological markers as early signs of organophosphate neurotoxicity

AU - Nagymajtényi, L.

AU - Dési, I.

AU - Lorencz, Rózsa

PY - 1988

Y1 - 1988

N2 - The central and peripheral nervous system effects of acute and subchronic exposure to three organic phosphoro-acid esters (dimethoate, dichlorvos, parathion-methyl) were studied. CNS-dependent variables included mean EEG amplitude, mean frequency of the EEG, and the activity (power density) of six component frequency bands. Peripheral nervous system evaluations included determinations of conduction velocity, and both relative and absolute refractory periods. Cholinesterase activity was measured in blood, brain and other organs. The results indicate that acute large doses of these agents produce substantial changes in these measures of CNS and PNS function. In subchronic experiments it was found that a six weeks administration of 1 50 LD50 of the chemicals induced early functional changes in both the central and the peripheral nervous systems. It is recommended that when cholinesterase inhibition is detected in humans, functional evaluations of CNS and PNS should follow.

AB - The central and peripheral nervous system effects of acute and subchronic exposure to three organic phosphoro-acid esters (dimethoate, dichlorvos, parathion-methyl) were studied. CNS-dependent variables included mean EEG amplitude, mean frequency of the EEG, and the activity (power density) of six component frequency bands. Peripheral nervous system evaluations included determinations of conduction velocity, and both relative and absolute refractory periods. Cholinesterase activity was measured in blood, brain and other organs. The results indicate that acute large doses of these agents produce substantial changes in these measures of CNS and PNS function. In subchronic experiments it was found that a six weeks administration of 1 50 LD50 of the chemicals induced early functional changes in both the central and the peripheral nervous systems. It is recommended that when cholinesterase inhibition is detected in humans, functional evaluations of CNS and PNS should follow.

KW - CNS Peripheral nervous system

KW - Conduction velocity

KW - Dichlorvos Parathion-methyl

KW - Dimethoate

KW - EEG EEG-bands

KW - Neurophysiological markers

KW - Organophosphates

KW - Refractory period

UR - http://www.scopus.com/inward/record.url?scp=0024161846&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024161846&partnerID=8YFLogxK

U2 - 10.1016/0892-0362(88)90004-9

DO - 10.1016/0892-0362(88)90004-9

M3 - Article

C2 - 3247000

AN - SCOPUS:0024161846

VL - 10

SP - 429

EP - 434

JO - Neurotoxicology and Teratology

JF - Neurotoxicology and Teratology

SN - 0892-0362

IS - 5

ER -