Neurophysiological markers as early signs of organophosphate neurotoxicity

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Abstract

The central and peripheral nervous system effects of acute and subchronic exposure to three organic phosphoro-acid esters (dimethoate, dichlorvos, parathion-methyl) were studied. CNS-dependent variables included mean EEG amplitude, mean frequency of the EEG, and the activity (power density) of six component frequency bands. Peripheral nervous system evaluations included determinations of conduction velocity, and both relative and absolute refractory periods. Cholinesterase activity was measured in blood, brain and other organs. The results indicate that acute large doses of these agents produce substantial changes in these measures of CNS and PNS function. In subchronic experiments it was found that a six weeks administration of 1 50 LD50 of the chemicals induced early functional changes in both the central and the peripheral nervous systems. It is recommended that when cholinesterase inhibition is detected in humans, functional evaluations of CNS and PNS should follow.

Original languageEnglish
Pages (from-to)429-434
Number of pages6
JournalNeurotoxicology and Teratology
Volume10
Issue number5
DOIs
Publication statusPublished - Jan 1 1988

Keywords

  • CNS Peripheral nervous system
  • Conduction velocity
  • Dichlorvos Parathion-methyl
  • Dimethoate
  • EEG EEG-bands
  • Neurophysiological markers
  • Organophosphates
  • Refractory period

ASJC Scopus subject areas

  • Toxicology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience

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