Neuropeptides may regulate neuropeptide metabolism in the brain

László Gráf, Koon Sea Hui, Amos Neidle, Abel Lajtha

Research output: Contribution to journalArticle

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Abstract

An aminopeptidase which cleaves the Tyr-Gly bond of Met-enkephalin was isolated from rat brain membranes. Various neuropeptides including ACTH-(1-24), ACTH-(1-10), somatostatin, Substance P and β-endorphin can inhibit this reaction with IC50 values of 0.7, 1.1, 2.1, 2.1 and 14.0 μM, respectively ACTH-(18-39) and bradykinin do not affect Met-enkephalin breakdown by this enzyme. The possibility is raised that these neuropeptides may regulate enkephalin and other neuropeptide levels in the brain by controlling their degradation under physiological conditions.

Original languageEnglish
Pages (from-to)169-173
Number of pages5
JournalNeuropeptides
Volume2
Issue number3-4
DOIs
Publication statusPublished - Mar 1982

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ASJC Scopus subject areas

  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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